75907-82-3Relevant articles and documents
Preparation method of vonoprazan fumarate intermediate
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Paragraph 0051-0054, (2021/06/21)
The invention provides a preparation method of a vonoprazan fumarate intermediate, and particularly provides a preparation method of a compound shown as a formula I. The preparation method comprises the following steps: reacting o-fluorobenzonitrile with
Method for synthesizing thiobenzamide derivative through CO2 regulation and control of substituted benzonitrile
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Paragraph 0037; 0038; 0040; 0041; 0042, (2019/01/24)
The invention discloses a method for synthesizing a thiobenzamide derivative through CO2 regulation and control of substituted benzonitrile. The method comprises the following steps: taking the substituted benzonitrile as a raw material, an inorganic sulfide as a sulfur source and CO2 as an auxiliary agent for reacting in the presence of a reaction solvent, and concentrating and purifying a reaction solution to obtain the thiobenzamide derivative. The reaction system disclosed by the invention is relatively simple, other catalysts are not added outside a reactant and the inorganic sulfide, themethod is suitable for synthesis of high-additional-value thiobenzamide containing a plurality of substituent groups, the reaction is carried out at low temperature and low pressure, and the risk coefficient is reduced.
A containing [...] the carboxamide derivative and its preparation and application (by machine translation)
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, (2016/10/31)
This invention relates to a kind of the carboxamide derivatives containing [...] and its preparation method and application. The oxalyl chloride, benzoic acid and ammonia-water reaction to make compound VI-1; compound VI-1 and olausson reagent reaction synthesis of compound VI-2; ethyl acetate to trifluoroacetoacetic reaction of the sulfonyl chloride compound VI-3; compound VI-2 and VI-3 VI-4 reaction to obtain compound, compound VI-4 with methanol, sodium hydroxide reaction to make compound VI-5; compound VI-5 with anthranilic acid amide, acid the system results in the type pyridine (I); the simple and easily-obtained raw materials, the preparation method is simple, convenient post-treatment, the product yield is high, and the compound is having a bactericidal activity, against cucumber gray mold, cucumber most bacterial corner sclerostachya sickness and so on and has good effect for of, but also has anti-cancer activity, the research and development of new drug is providing the foundation. (by machine translation)
