881674-56-2 Usage
Description
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)is a light orange to yellow to green powder or crystal that acts as a reagent in the synthetic preparation of novel pyrrole derivatives. It is a potassium-competitive acid blocker (P-CAB) and is used in the therapy of acid-related diseases.
Uses
Used in Pharmaceutical Industry:
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)is used as a potassium ion-competitive acid blocker for the treatment of acid-related diseases such as gastric ulcer, duodenal ulcer, and reflux esophagitis. It helps to reduce the production of stomach acid, providing relief from symptoms and promoting healing of the affected areas.
Used in Chemical Synthesis:
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)is used as a reagent in the synthetic preparation of novel pyrrole derivatives. These derivatives have potential applications in various fields, including pharmaceuticals, materials science, and chemical research.
Preparation
Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Check Digit Verification of cas no
The CAS Registry Mumber 881674-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,1,6,7 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 881674-56:
(8*8)+(7*8)+(6*1)+(5*6)+(4*7)+(3*4)+(2*5)+(1*6)=212
212 % 10 = 2
So 881674-56-2 is a valid CAS Registry Number.
881674-56-2Relevant articles and documents
Preparation method of vonoprazan fumarate intermediate
-
Paragraph 0056-0066, (2021/06/21)
The invention provides a preparation method of a vonoprazan fumarate intermediate, and particularly provides a preparation method of a compound shown as a formula I. The preparation method comprises the following steps: reacting o-fluorobenzonitrile with
Preparation method of fumaric acid Vonoprazan intermediate
-
Paragraph 0061-0085, (2021/07/28)
The invention relates to a preparation method of a fumaric acid Vonoprazan intermediate. In order to solve the problems that in the reaction process, many byproducts are produced and the product is easy to degrade, in the post-treatment process, the pH va
Preparation method 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde
-
Paragraph 0072-0089, (2021/11/19)
The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde. The preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - for
