76006-11-6

Basic information

• Product Name: 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE
• Synonyms: 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE;1H-Pyrazolo[3,4-c]pyridine, 7-chloro-;7-chloro-1H-pyrazolo[3
• CAS NO: 76006-11-6
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.572
• Product Categories: Thiophenes ,Thiazolines/Thiazolidines
• Mol File: 76006-11-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 161-163℃
• Boiling Point: 357.485 °C at 760 mmHg
• Flash Point: 201.244 °C
• Appearance: /
• Density: 1.531
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.72
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE(76006-11-6)
• EPA Substance Registry System: 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE(76006-11-6)

Safety Data

• Hazardous Substances Data: 76006-11-6(Hazardous Substances Data)

Usage

General Description

7-Chloro-1H-pyrazolo[3,4-c]pyridine is a chemical compound that belongs to the class of organic compounds known as pyrazolopyridines. It is characterized by a pyrazole ring fused to a pyridine ring, with the distinctive addition of a chlorine atom at the 7th carbon position. This chemical is often used in research and development, particularly in the field of pharmaceuticals, due to its distinctive structure and chemical properties, including a strong affinity for bonding. Its exact molecular formula is C7H4ClN3 and its molecular weight is 169.58 g/mol. The typical properties of 7-Chloro-1H-pyrazolo[3,4-c]pyridine make it an important compound for use in the development of a range of chemical products.

InChI:InChI=1/C6H4ClN3/c7-6-5-4(1-2-8-6)3-9-10-5/h1-3H,(H,9,10)

Upstream product

• 21901-18-8 2-hydroxy-4-methyl-3-nitropyridine 
• 6635-86-5 2-amino-4-methyl-3-nitropyridine 
• 76006-00-3 3-acetamido-2-chloro-4-methylpyridine 
• 76006-12-7 1H-pyrazolo<3,4-c>pyridine-7(6H)-thione 
• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 76005-98-6 3-acetamido-2-methoxy-4-methylpyridine 
• 76006-10-5 7-methoxy-1H-pyrazolo<3,4-c>pyridine 
• 76006-09-2 1H-pyrazolo<3,4-c>pyridin-7(6H)-one 
• 76005-99-7 2-methoxy-3-amino-4-methylpyridine 

Downstream Products

• 1373333-62-0 7-chloro-2-methylpyrazolo[3,4-c]pyridine 
• 957760-15-5 7-chloro-1-methylpyrazolo[3,4-c]pyridine 

Relevant articles and documents

Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines

A series of new pyrazolo[3,4-c]pyridines bearing various 1, 3, 5 or 1, 3, 7 pattern substitutions, were designed and synthesized. Some of them showed interesting inhibitory activity mainly against glycogen synthase kinase 3 (GSK3)α/β as well as against cdc2-like kinases 1 (CLK1) and dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), with good selectivity and remarkable structure-activity relationships (SARs), without being cytotoxic. Molecular simulations in correlation with biological data revealed the importance of the existence of N1-H as well as the absence of a bulky 7-substituent.

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

COMPLEMENT PATHWAY MODULATORS AND USES THEREOF

The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.