76099-91-7 Usage
Description
(S)-(+)-2-(4'-iodophenyl)propanoic acid, an optical isomer of 2-(4'-iodophenyl)propanoic acid, is a phenylpropanoid compound with a specific rotation of +25°. It is characterized by its unique structure and properties, making it a versatile compound in various applications.
Uses
Used in Pharmaceutical Synthesis:
(S)-(+)-2-(4'-iodophenyl)propanoic acid is used as a key intermediate in the synthesis of various pharmaceuticals, particularly those targeting the central nervous system. Its unique structure allows for the development of drugs with specific mechanisms of action, potentially leading to more effective treatments for neurological disorders.
Used as a Chiral Building Block:
In organic synthesis, (S)-(+)-2-(4'-iodophenyl)propanoic acid serves as a valuable chiral building block. Its optical activity and structural features make it an ideal candidate for the creation of complex molecules with specific stereochemistry, which is crucial in the development of enantiomerically pure compounds with desired biological activities.
Used in Anti-inflammatory and Anti-cancer Research:
(S)-(+)-2-(4'-iodophenyl)propanoic acid has been studied for its potential anti-inflammatory and anti-cancer properties. Its ability to modulate various biological pathways and exhibit inhibitory effects on tumor growth and progression makes it a promising candidate for further research and development in the field of medicinal chemistry.
Used in Radiolabeling for Nuclear Imaging and Diagnostics:
The presence of the iodine atom in (S)-(+)-2-(4'-iodophenyl)propanoic acid makes it particularly useful in radiolabeling applications. It can be employed in the development of radiotracers for nuclear imaging and diagnostic purposes, allowing for the visualization and detection of various diseases and conditions at the molecular level.
Check Digit Verification of cas no
The CAS Registry Mumber 76099-91-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,0,9 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 76099-91:
(7*7)+(6*6)+(5*0)+(4*9)+(3*9)+(2*9)+(1*1)=167
167 % 10 = 7
So 76099-91-7 is a valid CAS Registry Number.
76099-91-7Relevant articles and documents
Enantioselective hydrolysis of various racemic α-substituted arylacetonitriles using Rhodococcus sp. CGMCC 0497
Wu, Zhong-Liu,Li, Zu-Yi
, p. 3305 - 3312 (2007/10/03)
The enantioselective hydrolysis of 17 racemic α-substituted arylacetonitriles by Rhodococcus sp. CGMCC 0497 is described. The corresponding (R)-amides and (S)-acids were obtained with excellent enantiomeric excess in most cases. The effect of steric and electronic factors on the outcome of the reactions are discussed here. The results prove that nitrile-converting enzymes are efficient tools for the synthesis of sterically unencumbered chiral α-arylpropionic acids and amides.
Enantioselective syntheses of 2-arylpropanoic acid non-steroidal antiinflammatory drugs and related compounds
Hamon, David P.G.,Massy-Westropp, Ralph A.,Newton, Josephine L.
, p. 12645 - 12660 (2007/10/02)
(S)-2-[4′-(2″-Methylpropyl)phenylpropanoic acid (ibuprofen) and (S)-2-(3′-benzoylphenyl)propanoic acid (ketoprofen) have been synthesised in high enantiomeric excess. Control of stereochemistry was achieved by a combination of Sharpless epoxidalion followed by catalytic hydrogenolysis of the introduced benzylic epoxide oxygen bond. Also, the coupling of organic compounds in the presence of palladium with enantiopure 2-(3-iodophenyl)propanoic and 2-(4-iodophenyl)propanoic acids, prepared by the methodology above, is a general method for the synthesis of optically active arylpropanoic acids.
