762286-32-8

Basic information

• Product Name: Carbamic acid, methyl[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
• CAS NO: 762286-32-8
• Molecular Formula: C17H26N2O2
• Molecular Weight: 290.406
• Mol File: 762286-32-8.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Carbamic acid, methyl[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, methyl[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester(762286-32-8)
• EPA Substance Registry System: Carbamic acid, methyl[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester(762286-32-8)

Safety Data

• Hazardous Substances Data: 762286-32-8(Hazardous Substances Data)

Upstream product

• 865-47-4 potassium tert-butylate 
• 77-78-1 dimethyl sulfate 
• 131878-23-4 (3R)-1-benzyl-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 144043-17-4 (3R)-1-benzyl-N-methylpyrrolidin-3-amine 

Downstream Products

• 1313412-63-3 (R)tert-butyl 1-(2-amino-6-(benzyloxymethyl)pyrimidin-4-yl)pyrroIidin-3yl(methyl)carbamate 
• 392338-15-7 tert-butyl [(3R)-pyrrolidin-3-yl]methylcarbamate 

Relevant articles and documents

Development of the Late-Phase Manufacturing Process of ZPL389: Control of Process Impurities by Enhanced Process Knowledge

The development of the late-phase manufacturing process of the drug candidate ZPL389 and the strategies for the control of impurities are outlined in detail. Selective salt formation at several stages was pivotal to controlling the process impurities. The extensive optimization of the N-methylation of a Boc-protected amine with dimethyl sulfate and of a nucleophilic aromatic substitution without the use of metal catalysts led to a robust, scalable process. The process was demonstrated on a >100 kg scale. Overall, improved drug substance quality, higher yield, and reduction of the process mass intensity were achieved.

2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES

Pyrazolopyrimidine derivatives of formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.

FURO[3,2-D]PYRIMIDINE DERIVATIVES

Furo[3,2-d]pyrimidine derivatives of formula I, wherein the meanings for the various substituents are as defined in the description. These compounds are useful as H4 receptor antagonists.