392338-15-7

Basic information

• Product Name: METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;(R)-3-Boc-methylamino-pyrrolidine;(R)-3-(N-Boc-N-methylamino)pyrrolidine;tert-butyl N-Methyl-N-[(3R)-pyrrolidin-3-yl]carbaMate;(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]pyrrolidine;(R)-N-(Methyl)-N-(pyrrolidin-3-yl)carbamic acid tert-butyl ester;tert-Butyl (R)-N-methyl-N-(pyrrolidin-3-yl)carbamate;tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate
• CAS NO: 392338-15-7
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Mol File: 392338-15-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 268℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.03
• Vapor Pressure: 0.00777mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.85±0.10(Predicted)
• CAS DataBase Reference: METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER(392338-15-7)
• EPA Substance Registry System: METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER(392338-15-7)

Safety Data

• Hazardous Substances Data: 392338-15-7(Hazardous Substances Data)

Usage

General Description

Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester, also known as Tert-butyl (3S)-3-{[(S)-1-hydroxyethyl]amino}-2-methyl-1-oxobutylcarbamate, is a chemical compound commonly used as a pharmaceutical intermediate in the production of drugs such as cetirizine and levocetirizine. It is a white crystalline substance with a molecular formula of C12H24N2O3 and a molecular weight of 244.33 g/mol. METHYL-PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER is considered to be relatively stable and is typically handled and stored in a controlled laboratory setting. It is important to handle this chemical with care and in accordance with all safety precautions and regulations, as it may cause irritation or harm if mishandled.

InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12(4)8-5-6-11-7-8/h8,11H,5-7H2,1-4H3/t8-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 144043-17-4 (3R)-1-benzyl-N-methylpyrrolidin-3-amine 
• 638217-49-9 benzyl (3R)-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine-1-carboxylate 
• 762286-32-8 (1-benzyl-(3R)-pyrrolidin-3-yl)methylcarbamic acid tert-butyl ester 

Downstream Products

• 910220-79-0 3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester 
• 1313412-63-3 (R)tert-butyl 1-(2-amino-6-(benzyloxymethyl)pyrimidin-4-yl)pyrroIidin-3yl(methyl)carbamate 
• 1239355-25-9 2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}-N-[(1R)-2-[(3R)-3-(methylamino)pyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide 
• 1240421-97-9 benzyl 4-(2-amino-6-((3R)-3-(tert-butoxycarbonyl(methyl)amino)pyrrolidin-1-yl)pyrimidin-4-yl)piperidin-1-carboxylate 
• 762285-62-1 {(S)-1-[((R)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester 
• 910220-80-3 4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-[(S)-1-((R)-3-methylamino-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-amide 

Relevant articles and documents

AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS

Aminoalkyipyrimidine derivatives of formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.

2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES

Pyrazolopyrimidine derivatives of formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.

FURO [3, 2-D] PYRIMIDINE DERIVATIVES AS H4 RECEPTOR ANTAGONISTS

Furo[3,2-d]pypnnidine derivatives of formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.