1239355-25-9

Basic information

• Product Name: 2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}-N-[(1R)-2-[(3R)-3-(methylamino)pyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide
• CAS NO: 1239355-25-9
• Molecular Weight: 577.003
• Mol File: 1239355-25-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}-N-[(1R)-2-[(3R)-3-(methylamino)pyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}-N-[(1R)-2-[(3R)-3-(methylamino)pyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide(1239355-25-9)
• EPA Substance Registry System: 2-{[2-chloro-4-(trifluoromethyl)phenyl]oxy}-N-[(1R)-2-[(3R)-3-(methylamino)pyrrolidin-1-yl]-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide(1239355-25-9)

Safety Data

• Hazardous Substances Data: 1239355-25-9(Hazardous Substances Data)

Upstream product

• 1452-94-4 ethyl 2-chloronicotinate 
• 84907-81-3 (2R)-3-benzyloxy-2-aminopropanoic acid methyl ester 
• 47173-80-8 N-Boc-D-serine(Bzl)-OH 
• 35852-58-5 2-chloro-4-trifluoromethylphenol 
• 1239355-60-2 2-(2-chloro-4-(trifluoromethyl)phenoxy)nicotinic acid 
• 1239355-52-2 (R)-3-(benzyloxy)-2-(2-(2-chloro-4-(trifluoromethyl)phenoxy)nicotinamido)propanoic acid 
• 392338-15-7 tert-butyl [(3R)-pyrrolidin-3-yl]methylcarbamate 

Relevant articles and documents

Discovery of a new class of glucosylceramide synthase inhibitors

A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.