76252-28-3

Basic information

• Product Name: Benzene, 4-(1-butenyl)-1,2-dimethoxy-, (E)-
• CAS NO: 76252-28-3
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol File: 76252-28-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 4-(1-butenyl)-1,2-dimethoxy-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-(1-butenyl)-1,2-dimethoxy-, (E)-(76252-28-3)
• EPA Substance Registry System: Benzene, 4-(1-butenyl)-1,2-dimethoxy-, (E)-(76252-28-3)

Safety Data

• Hazardous Substances Data: 76252-28-3(Hazardous Substances Data)

Upstream product

• 54419-22-6 1-(3,4-dimethoxy-phenyl)-butan-1-ol 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 97-94-9 triethyl borane 
• 59056-76-7 1,2-dimethoxy-4-butylbenzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 91-16-7 1,2-dimethoxybenzene 
• 54419-21-5 1-(3,4-dimethoxyphenyl)butan-1-one 

Relevant articles and documents

Euodenine A: A small-molecule agonist of human TLR4

A small-molecule natural product, euodenine A (1), was identified as an agonist of the human TLR4 receptor. Euodenine A was isolated from the leaves of Euodia asteridula (Rutaceae) found in Papua New Guinea and has an unusual U-shaped structure. It was synthesized along with a series of analogues that exhibit potent and selective agonism of the TLR4 receptor. SAR development around the cyclobutane ring resulted in a 10-fold increase in potency. The natural product demonstrated an extracellular site of action, which requires the extracellular domain of TLR4 to stimulate a NF-κB reporter response. 1 is a human-selective agonist that is CD14-independent, and it requires both TLR4 and MD-2 for full efficacy. Testing for immunomodulation in PBMC cells shows the induction of the cytokines IL-8, IL-10, TNF-α, and IL-12p40 as well as suppression of IL-5 from activated PBMCs, indicating that compounds like 1 could modulate the Th2 immune response without causing lung damage.

An effective system to synthesize hypolipidemic active α-asarone and related methoxylated (E)-arylalkenes

Methoxylated (E)-arylalkenes (1a-1k) were prepared in two steps by an improved Grignard reaction comprising the reverse addition of alkylmagnesium bromide to benzaldehydes (2a-2k) in anhydrous ether and toluene into arylalkanols (3a-3k) in high yield, followed by dehydration with silica gel under microwave irradiation for 3-12 min, depending upon the substituents attached to the aromatic ring to afford hypolipidemic active α-asarone (1a) and related methoxylated (E)-arylalkenes (1b-1k).

Further characterization of the constituents of a Thai medicinal plant, Zingiber cassumunar Roxb

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