54419-21-5

Basic information

• Product Name: 3',4'-dimethoxybutyrophenone
• Synonyms: 3',4'-dimethoxybutyrophenone;1-(3,4-Dimethoxyphenyl)-1-butanone
• CAS NO: 54419-21-5
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25364
• EINECS: 259-159-1
• Mol File: 54419-21-5.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3',4'-dimethoxybutyrophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-dimethoxybutyrophenone(54419-21-5)
• EPA Substance Registry System: 3',4'-dimethoxybutyrophenone(54419-21-5)

Safety Data

• Hazardous Substances Data: 54419-21-5(Hazardous Substances Data)

Usage

General Description

3',4'-Dimethoxybutyrophenone is a chemical compound with the molecular formula C13H16O3. It is a synthetic derivative of butyrophenone and belongs to the class of psychoactive substances. The compound is known for its sedative and tranquilizing effects and is used in some countries as a sedative and antiemetic medication. It acts as a dopamine antagonist, blocking the effects of dopamine in the brain, and is believed to contribute to its sedative properties. 3',4'-Dimethoxybutyrophenone is also used as a research chemical to study the effects of dopamine antagonists and their potential therapeutic applications. Due to its psychoactive properties, the compound is considered to have abuse potential and is regulated in some jurisdictions.

Upstream product

• 106-31-0 butanoic acid anhydride 
• 91-16-7 1,2-dimethoxybenzene 
• 141-75-3 butyryl chloride 
• 927-77-5 n-propylmagnesium bromide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 4378-55-6 5-(3,4-dimethoxy-phenyl)-5-oxo-pentanoic acid 
• 17386-89-9 4-Butyroylpyrocatechol 
• 74-88-4 methyl iodide 
• 68719-74-4 1,2-Dimethoxy-4-((E)-pent-1-enyl)-benzene 
• 497-19-8 sodium carbonate 
• 16613-23-3 3,4-Dimethoxyphenyl-2-piperidinopropyl-keton 
• 69638-92-2 1,2-butyrideneacetate 
• 107-92-6 butyric acid 

Downstream Products

• 172988-62-4 ethyl 5-(3,4-dimethoxyphenyl)-4-ethyl-3,5-dioxopentanoate 
• 76252-28-3 trans-4-(3′,4′-dimethoxyphenyl)but-3-ene 
• 59056-76-7 1,2-dimethoxy-4-butylbenzene 
• 23474-83-1 2-bromo-1-(3,4-dimethoxyphenyl)butan-1-one 
• 1604832-27-0 (E)-N-(1-(3,4-dimethoxyphenyl)butylidene)-2,2-diethoxyethanamine 
• 1613322-14-7 C₁₄H₂₂O₄ 
• 101589-34-8 2-butyl-4,5-dimethoxy-benzenesulfonic acid amide 
• 2525-05-5 1,2-dihydroxy-4-butylbenzene 
• 101268-19-3 2-butyl-4,5-dimethoxy-benzaldehyde 
• 107275-71-8 2-butyl-4,5-dimethoxy-trans-cinnamic acid 
• 54419-22-6 1-(3,4-dimethoxy-phenyl)-butan-1-ol 

Relevant articles and documents

Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Substituent effects at the benzyl position and aromatic ring of silane-coupling agents containing 2-nitrobenzyl esters on photosensitivity and hydrophobic surface of a self-assembled monolayer (SAM)

Silane-coupling agents with 2-nitrobenzyl esters containing alkyl substituents at the benzyl position and alkoxy and/or fluoroalkoxy groups of the aromatic ring were synthesized to prepare a self-assembled monolayer (SAM) on quartz glass, silicon wafer and thermally oxidized silicon wafer. The resulting photosensitive SAMs before and after photoirradiation were characterized by contact angle measurement, UV spectroscopy, X-ray photoelectron spectroscopy (XPS), and X-ray reflectivity (XRR). Photosensitivity of the SAM was influenced by substituents at the benzyl position and aromatic ring as well as the irradiation conditions in air or solution and substrates employed. Silane-coupling agents with bulky substituent at the benzyl position and double fluoroalkoxy chains are preferable in terms of the photosensitivity and hydrophobic surface.

SUBSTITUTED 6, 7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE 10A)

The invention relates to compounds of the formula or a pharmaceutically acceptable salt thereof, wherein R′, R1 through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.