7639-71-6Relevant articles and documents
Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol
Abla, Nada,Bashyam, Sridevi,Charman, Susan A.,Greco, Béatrice,Hewitt, Philip,Jiménez-Díaz, Maria Belén,Katneni, Kasiram,Kubas, Holger,Picard, Didier,Sambandan, Yuvaraj,Sanz, Laura,Smith, Dennis,Wang, Tai,Willis, Paul,Wittlin, Sergio,Spangenberg, Thomas
, p. 1304 - 1308 (2017)
With ~429,000 deaths in 2016, malaria remains a major infectious disease where the need to treat the fever symptoms, but also to provide relevant post-treatment prophylaxis, is of major importance. An azepanylcarbazole amino alcohol is disclosed with a long- and fast-acting in vivo antiplasmodial efficacy and meets numerous attributes of a desired post-treatment chemoprophylactic antimalarial agent. The synthesis, the parasitological characterization, and the animal pharmacokinetics and pharmacodynamics of this compound are presented along with a proposed target.
ORGANIC COMPOUNDS, LIGHT EMITTING DIODE AND LIGHT EMITTING DEVICE HAVING THE COMPOUNDS
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Paragraph 0227-0231, (2020/08/07)
The present invention relates to an organic compound having a condensed aromatic core with a fluorene moiety and substituted with one or more functional groups having excellent hole transport properties, and a light emitting diode and a light emitting device using the same. According to the present invention, the organic compound can be introduced into a light emitting diode by using a solution process, and has a very deep HOMO energy level. When the organic compound of the present invention is applied to a hole transport layer, a band gap of the HOMO energy level between the hole transport layer and a light emitting material layer can be reduced, and thus holes and electrons can be injected into the light emitting material layer in a balanced manner. Accordingly, the light emitting diode and the light emitting device capable of low-voltage driving with higher light emitting efficiency can be implemented.COPYRIGHT KIPO 2020
Amination of Aryl Boronic Acids with Alkylnitrites: A Convenient Complement to Cu-Promoted Reductive Amination
Levitskiy, Oleg A.,Magdesieva, Tatiana V.
, p. 10028 - 10032 (2019/12/24)
Copper-catalyzed amination of aryl boronic acids with alkylnitrites leading to symmetrical diarylamines with a practical 50-80% yield was elaborated. Two C(sp2)-N bonds are formed in the one-pot process under mild conditions. This new approach to diarylamines is a complement to the Cu-assisted reductive amination of aryl boronic acids avoiding preliminary synthesis of nitrosoarenes. The possible reaction scheme based on quantum chemical calculations was suggested, clarifying key intermediates.