76574-42-0

Basic information

• Product Name: 2-(3-bromo-2-methyl-phenyl)acetonitrile
• Synonyms: 2-(3-bromo-2-methyl-phenyl)acetonitrile
• CAS NO: 76574-42-0
• Molecular Weight: 210.073
• Mol File: 76574-42-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(3-bromo-2-methyl-phenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromo-2-methyl-phenyl)acetonitrile(76574-42-0)
• EPA Substance Registry System: 2-(3-bromo-2-methyl-phenyl)acetonitrile(76574-42-0)

Safety Data

• Hazardous Substances Data: 76574-42-0(Hazardous Substances Data)

Usage

Appearance

White to pale yellow solid

Molecular weight

215.09 g/mol

Usage

Intermediate in organic synthesis for pharmaceuticals and agrochemicals

Chemical structure

Benzene ring with a bromine and a methyl group attached, and a cyano group at the alpha position to the benzene ring

Potential applications

Synthesis of new drugs and active pharmaceutical ingredients in the pharmaceutical industry

Verification

Precise uses and properties should be verified from reliable sources before use.

Upstream product

• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 83647-40-9 3-bromo-2-methylbenzaldehyde 
• 1148024-99-0 (3-bromo-2-methyl-phenyl)methyl methanesulfonate 
• 773837-37-9 sodium cyanide 
• 112299-62-4 1-bromo-3-(bromomethyl)-2-methylbenzene 
• 83647-43-2 3-bromo-2-methylbenzyl alcohol 
• 576-23-8 2,3-dimethylbromobenzene 
• 151-50-8 potassium cyanide 

Relevant articles and documents

Rational Design of Cell-Active Inhibitors of PARP10

Poly-ADP-ribose polymerases (PARPs 1-16) have emerged as major regulators of diverse cellular processes. PARPs can be subclassified based on their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylation). While much is

ISOPROPYL TRIAZOLO PYRIDINE COMPOUNDS

The present invention provides a compound of the Formula (I) below: Wherein R1 is selected from the group consisting of H, CH3, CN, CH2CN, C(CH3)2CN, and F; R2 is selected from the group consisting of H, O(C1-C3alkyl)R5, CH2CN, and CN; R3 is selected from the group consisting of H, OCH3, CN, C(CH3)2CN, and CH2CN; R4 is selected from the group consisting of H and CH3; R5 is selected from the group consisting of H, CN, C(CH3)2CN, OCH3, S(O)2CH3, and C(CH3)2OH; provided that at least one selected from the group consisting of R1, R2, R3 and R4 is H; or a pharmaceutically acceptable salt thereof, methods of treating diabetes using the compound and a process for preparing the compound.

Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives

A series of 51 6-arylpyridopyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat.A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyridopyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg.Normalized blood pressure levels could then be maintained by single daily oral doses.The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.