767282-94-0

Basic information

• Product Name: (S)-3-AMINO-3-(2-NAPHTHYL)-PROPIONIC ACID
• Synonyms: (S)-3-AMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID;(S)-3-AMINO-3-(2-NAPHTHYL)-PROPIONIC ACID;H-D-GLY(2-NAPH)-(C*CH2)OH;H-D-NPG(2)-(C*CH2)-OH;H-BETA-ALA-(2-NAPHTHYL)-OH;H-b-Ala-(2-naphthyl)-OH;(S)-3-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC ACID
• CAS NO: 767282-94-0
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.25
• Mol File: 767282-94-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-3-AMINO-3-(2-NAPHTHYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-AMINO-3-(2-NAPHTHYL)-PROPIONIC ACID(767282-94-0)
• EPA Substance Registry System: (S)-3-AMINO-3-(2-NAPHTHYL)-PROPIONIC ACID(767282-94-0)

Safety Data

• Hazardous Substances Data: 767282-94-0(Hazardous Substances Data)

Usage

General Description

"(S)-3-amino-3-(2-naphthyl)-propionic acid" is a chemical compound that belongs to the family of amino acids. It is an optically active compound with the "S" configuration, and it contains a 2-naphthyl group attached to a propionic acid moiety. (S)-3-AMINO-3-(2-NAPHTHYL)-PROPIONIC ACID is utilized in the synthesis of various pharmaceuticals and organic compounds due to its structural and functional properties. (S)-3-amino-3-(2-naphthyl)-propionic acid plays a crucial role in the realm of medicinal chemistry and drug development, and it is studied for its potential therapeutic applications in various diseases and conditions. Its precise chemical structure and properties make it an important compound for research and development in the field of chemistry and biology.

Upstream product

• 129042-57-5 3-amino-3-(2-naphthyl)propionic acid 
• 141-82-2 malonic acid 
• 66-99-9 β-naphthaldehyde 
• 51557-26-7 3-(2-naphthyl)acrylic acid 

Downstream Products

• 767282-94-0 (R)-3-amino-3-(2-naphthyl)propanoic acid 

Relevant articles and documents

Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase

In the last two decades, trans-sialidase of Trypanosoma cruzi (TcTS) has been an important pharmacological target for developing new anti-Chagas agents. In a continuous effort to discover new potential TcTS inhibitors, 3-amino-3-arylpropionic acid derivatives (series A) and novel phthaloyl derivatives (series B, C and D) were synthesized and molecular docking, TcTS enzyme inhibition and determination of trypanocidal activity were carried out. From four series obtained, compound D-11 had the highest binding affinity value (?11.1 kcal/mol) compared to reference DANA (?7.8 kcal/mol), a natural ligand for TS enzyme. Furthermore, the 3D and 2D interactions analysis of compound D-11 showed a hydrogen bond, π-π stacking, π-anion, hydrophobic and Van der Waals forces with all important amino acid residues (Arg35, Arg245, Arg314, Tyr119, Trp312, Tyr342, Glu230 and Asp59) on the active site of TcTS. Additionally, D-11 showed the highest TcTS enzyme inhibition (86.9% ± 5) by high-performance ion exchange chromatography (HPAEC). Finally, D-11 showed better trypanocidal activity than the reference drugs nifurtimox and benznidazole with an equal % lysis (63 ± 4 and 65 ± 2 at 10 μg/mL) and LC50 value (52.70 ± 2.70 μM and 46.19 ± 2.36 μM) on NINOA and INC-5 strains, respectively. Therefore, D-11 is a small-molecule with potent TcTS inhibition and a strong trypanocidal effect that could help in the development of new anti-Chagas agents.

Ruthenium-catalyzed asymmetric epoxidation of olefins using H 2O2, part I: Synthesis of new chiral N,N,N,-tridentate pybox and pyboxazine ligands and their ruthenium complexes

The synthesis of chiral tridentate N,N,N-pyridine-2.6-bisoxazolines 3 (pyhox ligands) and N,N,N-pyridine-2.6-bisoxazines 4 (pyboxazine ligands) is described in detail. These novel ligands constitute a useful tool-box for the application in asymmetric catalysis. Compounds 3 and 4 are conveniently prepared by cyclization of enantiomerically pure α- or β-amino al cohols with dimethyl pyridine-2,6-dicarboximidate. The corresponding ruthenium complexes are efficient asymmetric epoxidation catalysts and have been prepared in good yield and fully char acterized by spectroscopic means. Four of these ruthenium complexes have been characterized by X-ray crystallography. For the first time the molecular structure of a pyboxazine complex (2,6-bis-[(4S)-4-phenyl-5,6- dihydro-4H-[1,3]oxazinyl]pyridine)(pyridine-2,6-dicarboxylate)ruthenium (S)-2aa, is presented.

META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS

The present invention relates to a class of compounds represented by the Formula Ior a pharmaceutically acceptable salt thereof, whereinA ispharmaceutical compositions thereof and methods of using such compounds and compositions as alphavbeta3 antagonists.