768-03-6

Basic information

• Product Name: 1-Phenyl-2-propen-1-one
• Synonyms: 2-propenophenone;acrylophenone;ketone,phenylvinyl;phenylvinylketone;1-phenyl-2-propen-1-one;3-oxo-3-phenylpropene;1-phenylprop-2-en-1-one;1-Phenyl-2-propen-1-
• CAS NO: 768-03-6
• Molecular Formula: C₉H₈O
• Molecular Weight: 132.16
• EINECS: 212-190-4
• Mol File: 768-03-6.mol
• Article Data: 271

Chemical Properties

• Boiling Point: 204.08°C (rough estimate)
• Flash Point: 73.7 °C
• Appearance: /
• Density: 1.0270 (rough estimate)
• Vapor Pressure: 0.29mmHg at 25°C
• Refractive Index: 1.5181 (estimate)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Light and Temperature Sensitive
• CAS DataBase Reference: 1-Phenyl-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2-propen-1-one(768-03-6)
• EPA Substance Registry System: 1-Phenyl-2-propen-1-one(768-03-6)

Safety Data

• Hazardous Substances Data: 768-03-6(Hazardous Substances Data)

Usage

Description

1-Phenyl-2-propen-1-one, also known as cinnamaldehyde, is an organic compound that is a colorless to yellow liquid with a strong, sweet, and pungent odor. It is a derivative of acetophenone and is characterized by its aromatic ring and a carbonyl group attached to a vinyl group. This unique structure endows it with versatile chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
1-Phenyl-2-propen-1-one is used as a chemical reagent for the synthesis of pharmaceutical agents. It plays a crucial role in the preparation of various therapeutic compounds, such as functionalized aminoindolizines and pyrano[3,2-x]coumarins. These compounds have potential applications in the development of new drugs for the treatment of various diseases and conditions.
Used in Chemical Synthesis:
1-Phenyl-2-propen-1-one is also used as an intermediate in the synthesis of other organic compounds, such as dyes, perfumes, and flavorings. Its reactivity and versatility make it a valuable building block in the chemical industry for creating a wide range of products with diverse applications.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1602, 1973 DOI: 10.1021/jo00948a033Synthetic Communications, 23, p. 543, 1993 DOI: 10.1080/00397919308009811

Safety Profile

A poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

InChI:InChI=1/C9H8O/c1-2-9(10)8-6-4-3-5-7-8/h2-7H,1H2

Upstream product

• 14088-57-4 2-diazo-1-phenyl-1-propanone 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 936-59-4 3-chloropropiophenone 
• 5650-41-9 3-hydroxy-1-phenylpropan-1-one 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 60-29-7 diethyl ether 
• 24472-77-3 trimethyl-(2-oxo-2-phenylethyl)-ammonium bromide 
• 591-51-5 phenyllithium 
• 50-00-0 formaldehyd 
• 98-86-2 acetophenone 
• 67-56-1 methanol 
• 3893-35-4 1-diazo-1-phenyl-2-propanone 
• 300-57-2 allylbenzene 
• 29568-65-8 α-Bromopropiophenone cyclic ethylene acetal 

Downstream Products

• 60868-01-1 3-(4-methylpiperazin-1-yl)-1-phenylpropan-1-one 
• 111510-92-0 3-(5-methylfuran-2-yl)-1-phenylpropan-1-one 
• 97785-35-8 1,3-dimethyl-7-(3-oxo-3-phenyl-propyl)-3,7-dihydro-purine-2,6-dione 
• 6056-35-5 endo-2-benzoyl-5-norbornene 
• 101891-03-6 phenyl-(6-phenyl-3,4-dihydro-2H-pyran-2-yl)-ketone thiosemicarbazone 
• 3506-36-3 3-dimethylaminopropiophenone 
• 831-14-1 cyclohex-3-en-1-yl(phenyl)methanone 
• 2538-52-5 1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 58337-98-7 1,2,5-triphenylpentane-1,5-dione 
• 99069-98-4 1-methoxymethyl-2-oxo-2-phenyl-ethylmercury ⁽¹⁺⁾; bromide 
• 4055-00-9 6-phenyl-3,4-dihydropyran-2-one 
• 855288-74-3 phenyl[1, 1’; 4’, 1’’]terphenyl-2’-yl-methanone 
• 92963-42-3 4-nitro-1,4-diphenyl-butan-1-one 
• 495-40-9 propiophenone 

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