768-15-0 Usage
Description
(2S)-bicyclo[2.2.1]heptane-2-carboxamide, also known as bicuculline, is a chemical compound belonging to the class of amides. It is a potent convulsant and acts as a competitive antagonist of GABA receptors, particularly the GABAA receptor. Bicuculline is widely utilized in neuroscience research to block inhibitory neurotransmission in the central nervous system, facilitating the study of excitatory neurotransmission effects.
Uses
Used in Neuroscience Research:
Bicuculline is used as a research tool for blocking inhibitory neurotransmission in the central nervous system. It helps scientists understand the role and impact of excitatory neurotransmission by inhibiting the GABAA receptors, which are responsible for inhibitory signaling.
Used in Pharmaceutical Development:
Bicuculline has potential therapeutic applications in the treatment of certain neurological disorders, such as epilepsy and Parkinson's disease. Its ability to modulate GABAergic signaling makes it a candidate for developing drugs that can address the imbalances in neurotransmission associated with these conditions.
However, due to its potent convulsant properties, bicuculline must be used with caution and under strict medical supervision to ensure safety and effectiveness in any therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 768-15-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 768-15:
(5*7)+(4*6)+(3*8)+(2*1)+(1*5)=90
90 % 10 = 0
So 768-15-0 is a valid CAS Registry Number.
768-15-0Relevant articles and documents
Hypervalent iodine catalyzed hofmann rearrangement of carboxamides using oxone as terminal oxidant
Yoshimura, Akira,Middleton, Kyle R.,Luedtke, Matthew W.,Zhu, Chenjie,Zhdankin, Viktor V.
, p. 11399 - 11404 (2013/02/23)
Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions. Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields.
