7710-36-3

Basic information

• Product Name: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine
• Synonyms: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine
• CAS NO: 7710-36-3
• Molecular Formula: C₁₃H₂₀ClN₅
• Molecular Weight: 281.78
• Mol File: 7710-36-3.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 465.4°C at 760 mmHg
• Flash Point: 235.3°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 7.69E-09mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine(7710-36-3)
• EPA Substance Registry System: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine(7710-36-3)

Safety Data

• Hazardous Substances Data: 7710-36-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H20ClN5/c14-11-15-12(18-7-3-1-4-8-18)17-13(16-11)19-9-5-2-6-10-19/h1-10H2

Upstream product

• 110-89-4 piperidine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 19371-31-4 2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine 
• 2975-41-9 2,3-dihydro-1H-inden-2-amine 

Downstream Products

• 65845-84-3 2-(2-(4-chlorobenzylidene)hydrazinyl)-4,6-di(piperidin-1-yl)-1,3,5-triazine 
• 54589-69-4 2-hydrazino-4,6-dipiperidino-1,3,5-triazine 
• 16268-88-5 4,6-di(piperidinyl)-1,3,5-triazin-2-amine 

Relevant articles and documents

A convenient synthesis of triazine-based dendrons and dendrimers via a convergent approach and a study of their interactions with tetrafluoro- benzoquinone

A convenient, efficient and convergent approach to prepare triazine-based dendrons and dendrimers is developed. The steric hindrance resulting from the presence of dioctylamino moieties in the peripheral regions allows the synthesis of soluble dendrons without employing protection and deprotection steps. The triazine-based dendrimers are prepared via reaction of N,N′- dimethylethane-1,2-diamine with the dendrons in a ratio of 1:2. Interactions of the dendrimers with tetrafluorobenzoquinone led to the appearance of new broad bands, red-shifted by approximately 180 nm, in the absorbance spectra. Georg Thieme Verlag Stuttgart.

Hybrid Quinazoline 1,3,5-Triazines as Epidermal Growth Factor Receptor (EGFR) Inhibitors with Anticancer Activity: Design, Synthesis, and Computational Study

We report a series of hybrid quinazoline-1,3,5-triazine derivatives as EGFR inhibitors, which were synthesised and tested by using a variety of in vitro, in silico, and in vivo techniques. The derivatives were found to be active against different cancer cell lines and nontoxic against normal ones, with compounds 7 c, 7 d, 7 e, and 7 j being the most potent ones. The derivatives were also evaluated for angiogenesis inhibition potency in chicken eggs, and molecular docking and dynamics simulation studies were carried out to elucidate the fundamental substituent groups essential for their bioactivity. Additionally, a SAR study of the derivatives was performed for future compound optimisation. These studies suggested that the derivatives have a high affinity towards EGFR with favourable pharmacological properties. The most active compound (7 e) was further evaluated for in vivo anticancer activity against DMBA-induced tumours in female Sprague-Dawley rats as well as its effects on plasma antioxidant status, biotransformation enzymes, and lipid profile. The study suggested that 7 e has lead properties against breast cancer and can serve as a starting compound for further development of anti-EGFR compounds.

Synthesis, X-ray crystal structures, and preliminary antiproliferative activities of new s-triazine-hydroxybenzylidene hydrazone derivatives

We herein report a new small library of Schiff-base compounds that encompasses s-triazine and (2 or 4)-hydroxylbenzylidene derivatives. These compounds were synthesized through a hydrazone linkage connecting both the s-triazine and hydroxybenzylidene deri