772-70-3

Basic information

• Product Name: Benzenepropanoyl chloride, 4-fluoro-
• Synonyms: 3-(4-Fluoro-phenyl)-propionyl chloride
• CAS NO: 772-70-3
• Molecular Formula: C₉H₈ClFO
• Molecular Weight: 186.6106232
• Mol File: 772-70-3.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 249.9±23.0 °C(Predicted)
• Appearance: /
• Density: 1.231±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenepropanoyl chloride, 4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoyl chloride, 4-fluoro-(772-70-3)
• EPA Substance Registry System: Benzenepropanoyl chloride, 4-fluoro-(772-70-3)

Safety Data

• Hazardous Substances Data: 772-70-3(Hazardous Substances Data)

Upstream product

• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 7116-38-3 ethyl 3-(4-fluorophenyl)propanoate 
• 459-57-4 4-fluorobenzaldehyde 
• 459-32-5 4-fluorocinnamic acid 

Downstream Products

• 1481-32-9 6-fluoroindan-1-one 
• 940853-03-2 3-(4-fluorophenyl)-N-(quinolin-8-yl)propanamide 
• 898768-92-8 1-cyclohexyl-3-(4-fluorophenyl)propan-1-one 
• 603999-08-2 5-[3-(4-fluorophenyl)propanoyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 852661-57-5 3-(4-fluorophenyl)-N-(2,2,2-trifluoroethyl)propanamide 
• 852660-43-6 N-cyclopropyl-3-(4-fluorophenyl)propionamide 
• 25468-67-1 3-(4-fluorophenyl)propanamide 
• 52085-94-6 6-fluoro-2,3-dihydro-1H-inden-1-ol 
• 52031-15-9 5-fluoro-1H-indene 
• 214286-83-6 ethyl-3--L-Phe(4-F)-L-(Tr-Gln)>-E-propenoate 
• 214286-87-0 (E)-(S)-4-[(2R,5S)-5-Cyclopentylsulfanylcarbonylamino-2-(4-fluoro-benzyl)-7-methyl-4-oxo-octanoylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester 
• 214286-82-5 ethyl-3--L-Phe(4-F)-L-(Tr-Gln)>-E-propenoate 
• 214286-86-9 (E)-(S)-4-[(2R,5S)-5-tert-Butoxycarbonylamino-2-(4-fluoro-benzyl)-7-methyl-4-oxo-octanoylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester 
• 223520-70-5 [1-benzyl-5-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-4-(4-fluoro-benzyl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

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Direct C-C Bond Formation from Alkanes Using Ni-Photoredox Catalysis

A method for direct cross coupling between unactivated C(sp3)-H bonds and chloroformates has been accomplished via nickel and photoredox catalysis. A diverse range of feedstock chemicals, such as (a)cyclic alkanes and toluenes, along with late-stage intermediates, undergo intermolecular C-C bond formation to afford esters under mild conditions using only 3 equiv of the C-H partner. Site selectivity is predictable according to bond strength and polarity trends that are consistent with the intermediacy of a chlorine radical as the hydrogen atom-abstracting species.