940853-03-2

Basic information

• Product Name: 3-(4-fluorophenyl)-N-(quinolin-8-yl)propanamide
• Synonyms: 3-(4-fluorophenyl)-N-(quinolin-8-yl)propanamide
• CAS NO: 940853-03-2
• Molecular Weight: 294.328
• Mol File: 940853-03-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-fluorophenyl)-N-(quinolin-8-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)-N-(quinolin-8-yl)propanamide(940853-03-2)
• EPA Substance Registry System: 3-(4-fluorophenyl)-N-(quinolin-8-yl)propanamide(940853-03-2)

Safety Data

• Hazardous Substances Data: 940853-03-2(Hazardous Substances Data)

Upstream product

• 578-66-5 8-amino quinoline 
• 772-70-3 3-(4-fluorophenyl)propanoyl chloride 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 153889-27-1 N-phthaloyl-DL-(4-fluorophenyl)alanine 

Downstream Products

• 1514927-02-6 1-(8-quinolinyl)-4-(4-fluorophenyl)azetidinone 
• 1453491-63-8 3-(4-fluorophenyl)-3-phenyl-N-(quinolin-8-yl)propanamide 

Relevant articles and documents

Directing Group Participated Benzylic C(sp3)-H/C(sp2)-H Cross-Dehydrogenative Coupling (CDC): Synthesis of Azapolycycles

An efficient method to construct azapolycycles via directing group participated benzylic C(sp3)-H/C(sp2)-H cross-dehydrogenative coupling reactions is described. The reaction proceeded through a palladium catalyzed C(sp3)-H activation followed by coupling with a C(sp2)-H bond of quinoline to afford the azapolycyclic compounds. The reaction works with a broad substrate scope affording the products in moderate to good yields with excellent diastereoselectivities. Control experiments further supported the proposed mechanism.

Synthesis of Alkyl-Substituted Pyridines by Directed Pd(II)-Catalyzed C-H Activation of Alkanoic Amides

A general alkylation protocol for substituted iodopyridines was developed (32 examples, 44-97% yield). The reaction is based on the Pd(II)-catalyzed C-H activation of 8-aminoquinoline-derived alkanoic amides and it employs a catalyst cocktail of Pd(OAc)2 (10 mol%), NaI (30 mol%), and (BuO)2POOH (20 mol%), with Ag2CO3 as base.