77342-93-9

Basic information

• Product Name: TETRAHYDRO-PYRAN-3-CARBALDEHYDE
• Synonyms: 2H-PYRAN-3-CARBOXALDEHYDE, TETRAHYDRO-;RARECHEM AK ML 0583;TETRAHYDRO-PYRAN-3-CARBALDEHYDE;2H-Pyran-3-carboxaldehyde, tetrahydro- (9CI);tetrahydro-2H-pyran-3-carbaldehyde;Tetrahydro-2H-pyran-3-carboxaldehyde;oxane-3-carbaldehyde;tetrahydropyran-3-carboxaldehyde
• CAS NO: 77342-93-9
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• Product Categories: ALDEHYDE
• Mol File: 77342-93-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 178.539 °C at 760 mmHg
• Flash Point: 66.389 °C
• Appearance: /
• Density: 1.097 g/cm³
• Vapor Pressure: 0.984mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: TETRAHYDRO-PYRAN-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-PYRAN-3-CARBALDEHYDE(77342-93-9)
• EPA Substance Registry System: TETRAHYDRO-PYRAN-3-CARBALDEHYDE(77342-93-9)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 77342-93-9(Hazardous Substances Data)

Usage

Description

TETRAHYDRO-PYRAN-3-CARBALDEHYDE is a versatile organic compound that serves as a key intermediate in the synthesis of various chemical compounds. It is characterized by its unique structure, which includes a tetrahydropyran ring and a carbaldehyde functional group. TETRAHYDRO-PYRAN-3-CARBALDEHYDE plays a crucial role in the development of pharmaceuticals and other chemical products due to its reactivity and ability to form derivatives.

Uses

Used in Pharmaceutical Industry:
TETRAHYDRO-PYRAN-3-CARBALDEHYDE is used as a key intermediate for the synthesis of a novel 5-lipoxygenase inhibitor. This application is significant because 5-lipoxygenase inhibitors have potential therapeutic benefits in treating various inflammatory conditions and diseases.
Used in Pest Control:
TETRAHYDRO-PYRAN-3-CARBALDEHYDE is used as a reactant in the synthesis of tetrahydropyran esters, which serve as attractants towards Blattella germanica (German cockroach) and Supella longipalpa (brown-banded cockroach). This application is valuable in the development of effective pest control strategies, particularly for these common household pests, by attracting and facilitating their elimination.

InChI:InChI=1/C6H10O2/c7-4-6-2-1-3-8-5-6/h4,6H,1-3,5H2

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 201230-82-2 carbon monoxide 
• 50-00-0 formaldehyd 
• 13417-49-7 5,6-dihydro-2H-pyran-3-carbaldehyde 
• 873397-34-3 racemic tetrahydropyran-3-carboxylic acid 

Downstream Products

• 1050493-77-0 2-(tetrahydro-2H-pyran-3-yl)ethanol 
• 116131-44-3 (±)-3-(bromomethyl)tetrahydro-2H-pyran 
• 7179-99-9 (tetrahydro-2H-pyran-3-yl)methanamine 
• 1401964-90-6 N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-[(tetrahydro-2H-pyran-3-yl)methyl]pyrazolo[5,1-b][1,3]thiazol-7-amine 
• 1030623-67-6 2-amino-6-mercapto-4-(tetrahydro-2H-pyran-3-yl)pyridine-3,5-dicarbonitrile 
• 14774-36-8 rac-(tetrahydro-2H-pyran-3-yl)methanol 
• 77342-83-7 1,2-Diphenyl-5-(tetrahydropyran-3-yl)pyrrol 
• 77342-82-6 2-Pentyl-1-phenyl-5-(tetrahydropyran-3-yl)pyrrol 
• 77342-81-5 2-Ethyl-1-phenyl-5-(tetrahydropyran-3-yl)pyrrol 
• 77342-80-4 1-Methyl-2-phenyl-5-(tetrahydropyran-3-yl)pyrrol 
• 77342-72-4 4-Phenyl-1-(tetrahydropyran-3-yl)-1,4-butandion 

Relevant articles and documents

Synthesis of an Azaphosphatriptycene and Its Rhodium Carbonyl Complex

A 10-aza-9-phosphatriptycene is accessible on a gram scale, in three laboratory steps from commercially available precursors. Infrared spectroscopy of a rhodium(I) carbonyl complex bearing this ligand reflects the weak σ-donor/strong π-acceptor character of the phosphine; the solid-state structure reveals moderate steric demand. This ligand supports highly active catalysts for the hydroformylation of cyclic alkenes.

COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS

A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.

Hydroformylation and hydroalkylcarbonylation of 3,4-dihydro[2H]pyran catalysed by Co2(CO)8 under syngas conditions

In the cobalt-catalysed hydroformylation of 3,4-dihydro[2H]pyran, the influence of different reaction parameters such as time, pressure, triphenylphosphine addition, catalyst and substrate concentration has been investigated. 2-formyl-tetrahydropyran, tetrahydropyran and a hydroalkylcarbonylation product were the main reaction products. The selectivity towards 2-formyl-tetrahydropyran formation is favoured at constant catalyst and substrate concentration. The coordination of the pyran's oxygen to the cobalt atom seems to be an important intermediate for the formation of 2-formyl-tetrahydropyran. Different substrate or catalyst concentrations promote the formation of other reduced products. The addition of triphenylphosphine to the catalyst leads to a less active species, which decreases the yield and promotes the hydroalkylcarbonylation reaction.