873397-34-3

Basic information

• Product Name: TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID
• Synonyms: TETRAHYDRO-PYRAN-3-CARBOXYLIC ACID;TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID;Tetrahydro-2H-pyran-3-car...;oxane-3-carboxylic acid;3-tetrahydropyrancarboxylic acid
• CAS NO: 873397-34-3
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.14
• Mol File: 873397-34-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 265℃
• Flash Point: 114℃
• Appearance: /
• Density: 1.185
• Vapor Pressure: 0.00282mmHg at 25°C
• Refractive Index: 1.472
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.35±0.20(Predicted)
• CAS DataBase Reference: TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID(873397-34-3)
• EPA Substance Registry System: TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID(873397-34-3)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 873397-34-3(Hazardous Substances Data)

Usage

Uses

Tetrahydropyran-3-carboxylic Acid was used as in the synthesis of β-hydroxyisovalerylshikonin analogues which display inhibitory activity towards cell lines DU-145 and HeLa.

InChI:InChI=1/C6H10O3/c7-6(8)5-2-1-3-9-4-5/h5H,1-4H2,(H,7,8)

Upstream product

• 14774-36-8 rac-(tetrahydro-2H-pyran-3-yl)methanol 
• 100313-48-2 5,6-dihydro-2H-pyran-3-carboxylic acid 
• 40915-37-5 5,6-dihydro-4H-pyran-3-carboxylic acid 
• 89464-26-6 tetrahydropyran-3-carbonitrile 
• 23462-75-1 5,6-dihydro-2H-pyran-3(4H)-one 
• 110-87-2 3,4-dihydro-2H-pyran 
• 19752-84-2 Oxan-3-ol 

Downstream Products

• 1305321-54-3 3-({2-[(benzyloxycarbonyl)amino]-3-phenylpropanoyl}-amino)tetrahydropyran-3-carboxylic acid 
• 1305321-47-4 N-methyl-N-phenyltetrahydropyran-3-carboxamide 
• 1305321-48-5 N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide 
• 1305321-46-3 N-methyl-N-phenyl-5-oxa-1-azaspiro[2.5]oct-1-en-2-amine 
• 1305321-49-6 N-{3-[(N-methyl-N-phenylamino)thioxomethyl]tetrahydropyran-3-yl}benzamide 
• 77342-93-9 tetrahydro-pyran-3-carbaldehyde 

Relevant articles and documents

Electrochemical Oxidation of Alcohols and Aldehydes to Carboxylic Acids Catalyzed by 4-Acetamido-TEMPO: An Alternative to "anelli" and "pinnick" Oxidations

An electrocatalytic method has been developed to oxidize primary alcohols and aldehydes to the corresponding carboxylic acids using 4-acetamido-2,2,6,6-tetramethylpiperidin-1-oxyl (ACT) as a mediator. The method successfully converts benzylic, aliphatic, heterocyclic, and other heteroatom-containing substrates to the corresponding carboxylic acids in aqueous solution at room temperature. The mild conditions enable retention of stereochemistry adjacent to the site of oxidation, as demonstrated in a 40 g-scale synthesis of a precursor to levetiracetam, a medication used to treat epilepsy.

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including CNS or neurodegeneration disorder.