1305321-48-5

Basic information

• Product Name: N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide
• Synonyms: N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide
• CAS NO: 1305321-48-5
• Molecular Weight: 235.35
• Mol File: 1305321-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide(1305321-48-5)
• EPA Substance Registry System: N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide(1305321-48-5)

Safety Data

• Hazardous Substances Data: 1305321-48-5(Hazardous Substances Data)

Upstream product

• 19752-84-2 Oxan-3-ol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 873397-34-3 racemic tetrahydropyran-3-carboxylic acid 
• 23462-75-1 5,6-dihydro-2H-pyran-3(4H)-one 
• 1305321-47-4 N-methyl-N-phenyltetrahydropyran-3-carboxamide 
• 89464-26-6 tetrahydropyran-3-carbonitrile 
• 1113050-14-8 tetrahydropyran-3-carboxylic acid chloride 

Downstream Products

• 1305321-54-3 3-({2-[(benzyloxycarbonyl)amino]-3-phenylpropanoyl}-amino)tetrahydropyran-3-carboxylic acid 
• 1305321-47-4 N-methyl-N-phenyltetrahydropyran-3-carboxamide 
• 1305321-46-3 N-methyl-N-phenyl-5-oxa-1-azaspiro[2.5]oct-1-en-2-amine 
• 1305321-49-6 N-{3-[(N-methyl-N-phenylamino)thioxomethyl]tetrahydropyran-3-yl}benzamide 

Relevant articles and documents

N-methyl-N-phenyl-5-oxa-1-azaspiro[2.5]oct-1-en-2-amine - Synthesis and reactions of a synthon for AN UNKNOWN α-AMINO ACID

The synthesis of the heterospirocyclic amino azirine N-methyl-N-phenyl-5- oxa-1-azaspiro[2.5]oct-1-en-2-amine (6a) was achieved from 3,4-dihydro-2H-pyrane (7) via N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide (11). The reactions of 6a with thiobenzoic acid and Z-Phe-OH, respectively, leading to the corresponding 3-benzoylaminotetrahydropyran-3-thiocarboxamide (13) and the diastereoisomeric dipeptide amides (14), respectively, demonstrate that 6a is a valuable synthon for the hitherto unknown 3-aminotetrahydropyrane-3-carboxylic acid. The structure of 13 was established by X-Ray crystallography. The Japan Institute of Heterocyclic Chemistry.