19752-84-2

Basic information

• Product Name: TETRAHYDRO-PYRAN-3-OL
• Synonyms: TETRAHYDRO-PYRAN-3-OL;3-Hydroxytetrahydropyran;3-Hydroxytetrahydropyrane;oxan-3-ol;(s)-Tetrahydro-pyran-3-ol;2H-Pyran-3-ol, tetrahydro-;Pyran-3-ol, tetrahydro-;Tetrahydro-2H-Pyran-3-Ol(WX642095)
• CAS NO: 19752-84-2
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.13
• Product Categories: Aliphatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 19752-84-2.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 189.416 °C at 760 mmHg
• Flash Point: 84.775 °C
• Appearance: /
• Density: 1.081 g/cm³
• Vapor Pressure: 0.156mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: 2-8°C
• PKA: 14.49±0.20(Predicted)
• CAS DataBase Reference: TETRAHYDRO-PYRAN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-PYRAN-3-OL(19752-84-2)
• EPA Substance Registry System: TETRAHYDRO-PYRAN-3-OL(19752-84-2)

Safety Data

• Hazardous Substances Data: 19752-84-2(Hazardous Substances Data)

Usage

Description

TETRAHYDRO-PYRAN-3-OL, also known as Tetrahydro-2H-pyran-3-ol, is a 3-substituted tetrahydropyran compound with a six-membered oxygen-containing ring structure. It is a versatile organic compound that plays a significant role in various chemical reactions and applications.

Uses

Used in Pharmaceutical Industry:
TETRAHYDRO-PYRAN-3-OL is used as a key intermediate in the synthesis of CRF1 (corticotropin-releasing factor type 1) receptor antagonists, which are important for the development of drugs targeting stress-related disorders and anxiety.
Used in Agrochemical Industry:
TETRAHYDRO-PYRAN-3-OL is used in the preparation of herbicides, which are essential for controlling unwanted plant growth in agricultural fields and maintaining crop productivity.
Used in Chemical Synthesis:
TETRAHYDRO-PYRAN-3-OL is used as a building block in the synthesis of various organic compounds, including pyrazolothiazole compounds, which have potential applications in different industries such as pharmaceuticals and agrochemicals.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 2282, 1970 DOI: 10.1021/jo00832a038

InChI:InChI=1/C5H10O2/c6-5-2-1-3-7-4-5/h5-6H,1-4H2

Upstream product

• 23462-75-1 5,6-dihydro-2H-pyran-3(4H)-one 
• 78870-52-7 (1SR,6RS)-3,7-dioxa-bicyclo[4.1.0]heptane 
• 1204-56-4 diacetoxy-2,3 tetrahydropyranne 
• 14697-46-2 1,2,5-pentanetriol 
• 27999-93-5 3-tetrahydropyranyl brosylate 
• 64-19-7 acetic acid 
• 110-87-2 3,4-dihydro-2H-pyran 
• 6790-38-1 1,2-epoxy-3-vinylpropane 

Downstream Products

• 87011-11-8 3-Phenylmethoxytetrahydropyran 
• 14697-46-2 1,2,5-pentanetriol 
• 873397-34-3 racemic tetrahydropyran-3-carboxylic acid 
• 1305321-54-3 3-({2-[(benzyloxycarbonyl)amino]-3-phenylpropanoyl}-amino)tetrahydropyran-3-carboxylic acid 
• 89464-26-6 tetrahydropyran-3-carbonitrile 
• 1305321-47-4 N-methyl-N-phenyltetrahydropyran-3-carboxamide 
• 1305321-48-5 N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide 
• 1305321-46-3 N-methyl-N-phenyl-5-oxa-1-azaspiro[2.5]oct-1-en-2-amine 
• 1305321-49-6 N-{3-[(N-methyl-N-phenylamino)thioxomethyl]tetrahydropyran-3-yl}benzamide 
• 1450723-92-8 C₁₁H₁₃BrOS 
• 1450723-94-0 C₁₁H₁₃BrO₃S 
• 1450723-97-3 C₁₂H₁₃NO₃S 
• 1450723-37-1 N-[(4-tetrahydropyran-3-ylsulfonylphenyl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450723-82-6 C₁₂H₁₇NO₃S 

Relevant articles and documents

Hydroxynitrile lyase catalysed synthesis of heterocyclic (R)- and (S)-cyanohydrins

Heterocyclic saturated five- and six-membered ring ketones sometimes bearing a methyl substituent were reacted with HCN under enzyme catalysis using recombinant hydroxynitrile lyase from Hevea brasiliensis, as a rule (S)-selective, and Prunus amygdalus, (R)-selective. The resulting cyanohydrins were stereochemically characterised. The steric outcome of these transformations was interpreted by molecular modelling. The resulting cyanohydrins were stereochemically characterised and the mechanistic course of the transformations interpreted by molecular modelling.

Hydroboration of Prochiral Olefins with Chiral Lewis Base-Borane Complexes: Relationship to the Mechanism of Hydroboration

Alcohols with up to 19percent enantiomeric excess were obtained on hydroboration/oxidation of representative prochiral olefins using N-isobornyl-N-methylaniline-borane or N-benzyl-N-isopropyl-α-methylbenzylamine-borane indicating that the Lewis base is present in the hydroboration transition state.

Substituted pyridine compound and its method and use thereof

The invention relates to a novel substitutive pyridine compound, and a pharmaceutically acceptable salt and a pharmaceutical preparation of the substitutive pyridine compound for regulating the activity of protein kinases and regulating signal responses between cells or in the cells. Meanwhile, the invention further relates to a pharmaceutical composition containing the compound provided by the invention, and a method for treating high proliferative diseases of mammals, especially human with the pharmaceutical composition.

N-methyl-N-phenyl-5-oxa-1-azaspiro[2.5]oct-1-en-2-amine - Synthesis and reactions of a synthon for AN UNKNOWN α-AMINO ACID

The synthesis of the heterospirocyclic amino azirine N-methyl-N-phenyl-5- oxa-1-azaspiro[2.5]oct-1-en-2-amine (6a) was achieved from 3,4-dihydro-2H-pyrane (7) via N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide (11). The reactions of 6a with thiobenzoic acid and Z-Phe-OH, respectively, leading to the corresponding 3-benzoylaminotetrahydropyran-3-thiocarboxamide (13) and the diastereoisomeric dipeptide amides (14), respectively, demonstrate that 6a is a valuable synthon for the hitherto unknown 3-aminotetrahydropyrane-3-carboxylic acid. The structure of 13 was established by X-Ray crystallography. The Japan Institute of Heterocyclic Chemistry.