7738-22-9 Usage
Description
BOC-SER(TBU)-OH, also known as (S)-tert-Butyl 2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoate, is a chemical compound that serves as a reactant in the synthesis of biomembrane-mimic polymers. It is characterized by its unique structure, which includes a tert-butyl group, a tert-butoxycarbonyl group, and a hydroxypropanoate moiety. BOC-SER(TBU)-OH plays a crucial role in the development of advanced materials for tissue engineering and bioimplants.
Uses
Used in Tissue Engineering and Bioimplants Industry:
BOC-SER(TBU)-OH is used as a reactant in the synthesis of biomembrane-mimic polymers for tissue engineering or bioimplants. Its unique structure allows it to contribute to the development of materials that closely resemble the properties of natural biomembranes, which are essential for the proper functioning of cells and tissues.
In the field of tissue engineering, BOC-SER(TBU)-OH helps in creating biocompatible and biodegradable scaffolds that support cell growth, differentiation, and tissue regeneration. These scaffolds can be tailored to mimic the mechanical and biochemical properties of the target tissue, promoting efficient integration and functionality within the host organism.
In the context of bioimplants, BOC-SER(TBU)-OH plays a vital role in the design and fabrication of implantable devices that exhibit excellent biocompatibility and minimal immune response. The biomembrane-mimic polymers synthesized using this compound can be used to create coatings for implants, reducing the risk of infection and improving the overall performance and longevity of the device.
Overall, BOC-SER(TBU)-OH is a valuable chemical compound with significant applications in the development of advanced materials for tissue engineering and bioimplants, contributing to improved patient outcomes and the advancement of medical technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 7738-22-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,3 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7738-22:
(6*7)+(5*7)+(4*3)+(3*8)+(2*2)+(1*2)=119
119 % 10 = 9
So 7738-22-9 is a valid CAS Registry Number.
7738-22-9Relevant articles and documents
Zirconium-Catalyzed Hydroalumination of C=O Bonds: Site-Selective De- O-acetylation of Peracetylated Compounds and Mechanistic Insights
Courant, Thibaut,Gavel, Marine,Renard, Romain M. Q.,Gandon, Vincent,Joosten, Antoine Y. P.,Lecourt, Thomas
, p. 9280 - 9288 (2021/06/30)
An unprecedented hydroalumination of C = O bonds catalyzed by zirconocene dichloride is reported herein and applied to the site-selective deprotection of peracetylated functional substrates. A mixed metal hydride, with 1:1 zirconium/aluminum stoichiometry
Aryloxy Triester Phosphoramidates as Phosphoserine Prodrugs: A Proof of Concept Study
Dhiani, Binar A.,James, Edward,Kadri, Hachemi,Lambourne, Olivia A.,Mehellou, Youcef,Miccoli, Ageo,Thornton, Peter J.
supporting information, (2020/03/30)
The specific targeting of protein-protein interactions by phosphoserine-containing small molecules has been scarce due to the dephosphorylation of phosphoserine and its charged nature at physiological pH, which hinder its uptake into cells. To address these issues, we herein report the synthesis of phosphoserine aryloxy triester phosphoramidates as phosphoserine prodrugs that are enzymatically metabolized to release phosphoserine. This phosphoserine-masking approach was applied to a phosphoserine-containing inhibitor of 14-3-3 dimerization, and the generated prodrugs exhibited improved pharmacological activity. Collectively, this provided a proof of concept that the masking of phosphoserine with biocleavable aryloxy triester phosphoramidate masking groups is a viable intracellular delivery system for phosphoserine-containing molecules. Ultimately, this will facilitate the discovery of phosphoserine-containing small-molecule therapeutics.
L-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of L-histidine and L-tryptophan
Hall, Colton,Wolfe, Hannah,Wells, Alyssa,Chien, Huan-Chieh,Colas, Claire,Schlessinger,Giacomini, Kathleen M.,Thomas, Allen A.
supporting information, p. 2254 - 2258 (2019/06/27)
A series of 1,2,3-triazole analogs of the amino acids L-histidine and L-tryptophan were modeled, synthesized and tested for L-type amino acid transporter 1 (LAT1; SLC7A5) activity to guide the design of amino acid-drug conjugates (prodrugs). These triazol
