773836-70-7

Basic information

• Product Name: 2-[2-(3H-Imidazol-4-yl)-ethyl]-5-phenyl-1H-imidazole
• CAS NO: 773836-70-7
• Molecular Weight: 238.292
• Mol File: 773836-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[2-(3H-Imidazol-4-yl)-ethyl]-5-phenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(3H-Imidazol-4-yl)-ethyl]-5-phenyl-1H-imidazole(773836-70-7)
• EPA Substance Registry System: 2-[2-(3H-Imidazol-4-yl)-ethyl]-5-phenyl-1H-imidazole(773836-70-7)

Safety Data

• Hazardous Substances Data: 773836-70-7(Hazardous Substances Data)

Upstream product

• 33550-96-8 4(5)-(β-Cyanoethyl)imidazole 
• 13518-55-3 4(5)-(β-Chloroethyl)imidazole 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

New histamine H3-receptor antagonists were synthesised and tested on rat brain membranes and on electrically stimulated guinea-pig ileum. The new compounds have a central polar group represented by a 2-alkylimidazole or a 2-thioimidazoline nucleus. The effect of the polar group basicity on the optimal length of the alkyl chain, connecting this group to a 4(5)-imidazolyl ring, was investigated. The best affinity values, obtained by displacement of [3H]-RAMHA from rat brain, were obtained for the 2-alkylimidazole derivatives (2a-f) with tetramethylene chain (pK(i) 8.03-8.97), having an intermediate basicity between that of the previously reported 2- thioimidazoles (1a-i) and that of 2-alkylthioimidazolines (3a-h). In contrast, a general lowering of affinity (pK(i) 5.90-7.63) was observed for compounds of the last series (3a-h), with a complex dependence on the terminal lipophilic group and chain length. (C) 2000 Elsevier Science S.A.