7781-29-5

Basic information

• Product Name: 2-AMINO-4-PHENYLAMINO-6-METHYLPYRIMIDINE
• Synonyms: 2-AMINO-4-PHENYLAMINO-6-METHYLPYRIMIDINE;6-METHYL-N4-PHENYL-2,4-PYRIMIDINEDIAMINE;2-Amino-4-anilino-6-methylpyrimidine;6-methyl-4-phenylaminopyrimidin-2-amine
• CAS NO: 7781-29-5
• Molecular Formula: C₁₁H₁₂N₄
• Molecular Weight: 200.24
• Mol File: 7781-29-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 441 °C at 760 mmHg
• Flash Point: 220.5 °C
• Appearance: /
• Density: 1.247 g/cm³
• Vapor Pressure: 5.65E-08mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 2-AMINO-4-PHENYLAMINO-6-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-PHENYLAMINO-6-METHYLPYRIMIDINE(7781-29-5)
• EPA Substance Registry System: 2-AMINO-4-PHENYLAMINO-6-METHYLPYRIMIDINE(7781-29-5)

Safety Data

• Hazardous Substances Data: 7781-29-5(Hazardous Substances Data)

Usage

General Description

2-AMINO-4-PHENYLAMINO-6-METHYLPYRIMIDINE is a chemical compound with the molecular formula C11H12N4. It is a pyrimidine derivative with a substituted amino group and a phenyl ring. 2-AMINO-4-PHENYLAMINO-6-METHYLPYRIMIDINE is commonly used in pharmaceutical research and development, particularly in the synthesis of potential drug candidates. It exhibits potential biological activities and is being studied for its therapeutic potential in various diseases and conditions. Its unique structure and properties make it a valuable molecule for medicinal chemistry and drug discovery.

InChI:InChI=1/C11H12N4/c1-8-7-10(15-11(12)13-8)14-9-5-3-2-4-6-9/h2-7H,1H3,(H3,12,13,14,15)

Upstream product

• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 
• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 10374-66-0 3-oxo-N-phenylbutanethioamide 
• 593-85-1 diguanidine carbonate 

Downstream Products

• 57084-42-1 4-anilino-1,6-dimethyl-1H-pyrimidin-2-one 
• 6633-70-1 5-bromo-N⁴-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine 
• 7781-30-8 5-bromo-6-methyl-N⁴-phenyl-pyrimidine-2,4-diamine 

Relevant articles and documents

Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors

Interleukin-1β converting enzyme contributes in various inflammatory and autoimmune diseases by maturing pro-inflammatory cytokines IL-1β, IL-18 and IL-33. Therefore, inhibition caspase-1 may provide a potential therapeutic strategy for the treatment of chronic inflammatory diseases. Here we have reported structure-based design, synthesis and biological evaluation of 2,4-diaminopyrimidine derivatives (6a-6w) as potential caspase-1 inhibitors. Six compounds 6m, 6n, 6o, 6p, 6q and 6r showed significant enzymatic inhibition with IC5 0 ranging from 0.022 to 0.078 μM. These compounds also displayed excellent cellular potency at sub-micromolar concentration. Moreover, molecular docking studies provided the useful binding insights specific for caspase-1 inhibition. All these results indicated that compounds 6m, 6n and 6o could be potential leads for the development of newer caspase-1 inhibitors as anti-inflammatory agents.