7784-82-9

Basic information

• Product Name: Z-PRO-LEU-GLY-OET
• Synonyms: N-CBZ-PRO-LEU-GLY ETHYL ESTER;Z-PRO-LEU-GLY-OET;Z-L-PROLYL-L-LEUCYL-GLYCYL ETHYL ESTER;z-pro-leu-gly ethyl ester;carbobenzyloxy-L-prolyl-L-leucylglycine ethyl ester;2-[[1-[(2-ethoxy-2-keto-ethyl)carbamoyl]-3-methyl-butyl]carbamoyl]pyrrolidine-1-carboxylic acid benzyl ester;phenylmethyl 2-[[1-[(2-ethoxy-2-oxo-ethyl)amino]-4-methyl-1-oxo-pentan-2-yl]carbamoyl]pyrrolidine-1-carboxylate;phenylmethyl 2-[[1-[(2-ethoxy-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
• CAS NO: 7784-82-9
• Molecular Formula: C₂₃H₃₃N₃O₆
• Molecular Weight: 447.52
• Product Categories: Dipeptides and Tripeptides;Peptides;Tripeptides
• Mol File: 7784-82-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 152-153℃
• Boiling Point: 660.5 °C at 760 mmHg
• Flash Point: 353.3 °C
• Appearance: /
• Density: 1.187 g/cm³
• Vapor Pressure: 2.55E-17mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-PRO-LEU-GLY-OET(CAS DataBase Reference)
• NIST Chemistry Reference: Z-PRO-LEU-GLY-OET(7784-82-9)
• EPA Substance Registry System: Z-PRO-LEU-GLY-OET(7784-82-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 7784-82-9(Hazardous Substances Data)

Usage

General Description

Z-PRO-LEU-GLY-OET is a synthetic chemical compound consisting of a series of amino acids. The "Z" group at the beginning indicates that the compound is protected, meaning it has a protective group attached to the amino group of the first amino acid (proline) to prevent unwanted reactions. The three amino acids in the compound are proline, leucine, and glycine, and the "OET" at the end indicates that the compound has an ethyl ester group attached to the carboxylic acid group of the last amino acid (glycine). This chemical compound can be used in peptide synthesis, drug development, and biochemical research.

InChI:InChI=1/C23H33N3O6/c1-4-31-20(27)14-24-21(28)18(13-16(2)3)25-22(29)19-11-8-12-26(19)23(30)32-15-17-9-6-5-7-10-17/h5-7,9-10,16,18-19H,4,8,11-15H2,1-3H3,(H,24,28)(H,25,29)

Upstream product

• 2867-06-3 Benzyloxycarbonylleucyl-glycine ethyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 1634-90-8 (S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanoic acid 
• 459-73-4 GlyOEt*HCl 
• 1738-87-0 Z-Leu-ONp 
• 623-33-6 glycine ethyl ester hydrochloride 
• 54769-32-3 6-nitro-1-(toluene-4-sulfonyloxy)-1H-benzotriazole 
• 2018-66-8 Z-Leu-OH 
• 53375-57-8 H-Leu-Gly-OEt 

Downstream Products

• 2002-44-0 melanostatin 
• 7801-38-9 Z-L-Pro-L-Leu-Gly 
• 14485-80-4 benzoyloxycarbonylprolyl-leucyl-glycine amide 

Relevant articles and documents

PROCESS FOR LARGE SCALE LIQUID PHASE SYNTHESIS OF CARBETOCIN AND ITS NOVEL INTERMEDIATES

A process for large scale liquid phase synthesis of Carbetocin is disclosed. Novel intermediates of formula (A), formula (B), and processes for their preparation are also disclosed.

Sulfonic acid esters

A novel process for the amidation or esterification which comprises reacting a compound having a carboxy group with a compound having an amino or imino group which can be acylated or with a compound having a hydroxy group in the presence of a sulfonic acid ester of the formula: wherein R1 is an organic group and R2 O-- is a residue of a strongly acidic N-hydroxy compound as a condensation agent, and a novel sulfonic acid ester useful as such a condensation agent and a process for the preparation thereof.