77868-40-7

Basic information

• Product Name: N-DesMethyl IoMeprol
• Synonyms: N-DesMethyl IoMeprol;N,N'-Bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide;N,N'-bis-(2,3-dihydroxypropyl)-5-(2-hydroxyacetylamino)-2,4,6-triiodoisophthalamide
• CAS NO: 77868-40-7
• Molecular Formula: C₁₆H₂₀I₃N₃O₈
• Molecular Weight: 763.05871
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals;Intermediate of Ioversol
• Mol File: 77868-40-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 784.1±60.0 °C(Predicted)
• Appearance: /
• Density: 2.3670 (rough estimate)
• Refractive Index: 1.7550 (estimate)
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Water
• PKA: 10.57±0.70(Predicted)
• Water Solubility: 17.68g/L(25 oC)
• CAS DataBase Reference: N-DesMethyl IoMeprol(CAS DataBase Reference)
• NIST Chemistry Reference: N-DesMethyl IoMeprol(77868-40-7)
• EPA Substance Registry System: N-DesMethyl IoMeprol(77868-40-7)

Safety Data

• Hazardous Substances Data: 77868-40-7(Hazardous Substances Data)

Usage

Description

N-DesMethyl IoMeprol is an intermediate compound that plays a crucial role in the synthesis of Iomeprol, a widely used X-ray contrast agent. It is characterized by its ability to enhance the visibility of internal structures during imaging procedures, thereby aiding in the diagnosis of various medical conditions.

Uses

Used in Pharmaceutical Industry:
N-DesMethyl IoMeprol is used as a key intermediate in the production of Iomeprol, a X-ray contrast agent, for improving the visualization of blood vessels, organs, and tissues during diagnostic imaging procedures. Its role in the synthesis process is essential for creating a safe and effective contrast medium that can be utilized in medical settings.
Used in Medical Imaging:
N-DesMethyl IoMeprol contributes to the development of Iomeprol, which is employed as a contrast agent in medical imaging techniques such as X-ray, computed tomography (CT), and angiography. The use of Iomeprol allows for clearer images and more accurate diagnoses, making it a valuable tool in the field of radiology and medical imaging.

Upstream product

• 87785-51-1 5-(acetoxyacetylamino)-N,N'-bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide 
• 78314-12-2 2-((3,5-bis (chlorocarbonyl)-2,4,6-triiodophenyl)amino)-2-oxoethyl acetate 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 
• 35453-19-1 2,4,6-triiodo-5-aminoisophthalic acid 

Downstream Products

• 87771-40-2 ioversol 
• 78649-41-9 iomeprol 

Relevant articles and documents

Process for the Monotopic Preparation of Intermediate Organo-Iodinated Compounds for the Synthesis of Ioversol

The invention relates to a process for the preparation of organo-iodinated compounds as well as the preparation intermediates thereof. More specifically, the invention relates to a process for the preparation of organo-iodinated compounds useful as preparation intermediates in the synthesis of the contrast product ioversol.

New Methods for Preparing an Intermediate of Contrast Medium and Methods for Preparing Contrast Medium

The present invention relates to a method for preparing an intermediate of contrast agent or contrast agent. Also, the manufacturing cost can be significantly reduced. , The manufacturing method of the present invention can greatly reduce the production cost of contrast agents and is suitable for mass production. (by machine translation)