78649-41-9Relevant articles and documents
Synthesis method of iomeprol
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, (2022/03/27)
The invention relates to a preparation method of iomeprol. The iomeprol is a non-ionic X-ray contrast agent with excellent safety and contrast effect. The invention relates to a synthesis method of iomeprol, which is characterized in that 5-amino-N, N '-bis (2, 3-dihydroxy propyl)-2, 4, 6-triiodo-1, 3-benzene dicarboxamide (compound II) is used as an initial raw material, chloroacetylation, methylation, hydrolysis and hydroxylation reactions are sequentially carried out to synthesize an iomeprol product, and the synthesis route is as follows. The chemical method for preparing iomeprol is realized through the following steps: acylation reaction, methylation reaction, hydrolysis reaction and hydroxylation reaction. The preparation method disclosed by the invention is stable in quality, high in yield, low in cost, small in pollution and easy to realize industrial production.
New Methods for Preparing an Intermediate of Contrast Medium and Methods for Preparing Contrast Medium
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Paragraph 0133-0136, (2020/10/07)
A manufacturing method of the present invention reduces treatment processes when manufacturing a contrast medium or an intermediate thereof, and thus generates less waste solvent, thereby being eco-friendly and capable of significantly reducing a manufacturing cost. Therefore, the manufacturing method of the present invention is economical and suitable for mass production since the production cost of the contrast medium can be greatly reduced.
preparation method of contrast agent
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Paragraph 0087; 0091; 0092; 0094; 0095; 0097; 0098, (2018/10/16)
The present invention relates to a method for producing a contrast medium with high purity and high efficiency, and since no methyl iodide and the like are used in a production process, no salt is generated or only a very small amount thereof is generated, and a high purity and high efficiency contrast medium can be produced without complicated purification and washing steps. In addition, a small amount of salt can be easily removed by washing with water.COPYRIGHT KIPO 2018