779341-90-1

Basic information

• Product Name: D-Valine, N-[(4-bromophenyl)sulfonyl]-, 1,1-dimethylethyl ester
• CAS NO: 779341-90-1
• Molecular Formula: C15H22BrNO4S
• Molecular Weight: 392.314
• Mol File: 779341-90-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: D-Valine, N-[(4-bromophenyl)sulfonyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Valine, N-[(4-bromophenyl)sulfonyl]-, 1,1-dimethylethyl ester(779341-90-1)
• EPA Substance Registry System: D-Valine, N-[(4-bromophenyl)sulfonyl]-, 1,1-dimethylethyl ester(779341-90-1)

Safety Data

• Hazardous Substances Data: 779341-90-1(Hazardous Substances Data)

Upstream product

• 817164-43-5 (R)-2-(4-bromophenylsulfonamido)-3-methylbutanoic acid 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 640-68-6 D-Val-OH 
• 2528-15-6 D-valine t-butyl ester 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 13518-40-6 t-butyl D-valinate hydrochloride 

Downstream Products

• 854371-72-5 (R)-2-[4'-(benzothiazol-2-yloxymethyl)-biphenyl-4-sulfonylamino]-3-methyl-butyric acid tert-butyl ester 
• 871574-46-8 tert-butyl N-[(4'-{[(1-benzofuran-2-ylcarbonyl)amino]methyl}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate 
• 871574-47-9 tert-butyl N-[(4'-{[(1-benzofuran-2-ylcarbonyl)oxy]methyl}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate 
• 854372-23-9 tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate 
• 871574-44-6 tert-butyl N-({4'-[(1-benzofuran-2-ylsulfonyl)oxy]-1,1'-biphenyl-4-yl}sulfonyl)-D-valinate 
• 854372-24-0 benzofuran-2-carboxylic acid 4'-(1-tert-butoxycarbonyl-2-methylpropylsulfamoyl)biphenyl-4-yl ester 
• 854371-76-9 D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester 

Relevant articles and documents

Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors

Matrix metalloproteinase-12 (MMP-12) can be considered an attractive target to study selective inhibitors useful in the development of new therapies for lung and cardiovascular diseases. In this study, a new series of arylsulfonamide carboxylates, with increased hydrophilicity resulting from conjugation with a β-N-acetyl-d-glucosamine moiety, were designed and synthesized as MMP-12 selective inhibitors. Their inhibitory activity was evaluated on human MMPs by using the fluorimetric assay, and a crystallographic analysis was performed to characterize their binding mode. Among these glycoconjugates, a nanomolar MMP-12 inhibitor with improved water solubility, compound 3 [(R)-2-(N-(2-(3-(2-acetamido-2-deoxy-β-d-glucopyranosyl)thioureido)ethyl)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid], was identified.

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors

Aggrecanases are recently discovered enzymes that cleave aggrecan, a key component of cartilage. Aggrecanase inhibitors may provide a unique means to halt the progression of cartilage destruction in osteoarthritis. The synthesis and evaluation of biphenyl

Biaryl sulfonamides and methods for using same

The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.