77976-04-6Relevant articles and documents
Tertiary-Amine-Initiated Synthesis of Acyl Fluorides from Carboxylic Acids and CF3SO2OCF3
Song, Hai-Xia,Tian, Ze-Yu,Xiao, Ji-Chang,Zhang, Cheng-Pan
supporting information, p. 16261 - 16265 (2020/12/01)
A convenient method for deoxyfluorination of aromatic and aliphatic carboxylic acids with CF3SO2OCF3 in the presence of a suitable base at room temperature has been developed. The reaction allows a straightforward access to a variety of acyl fluorides and proves that CF3SO2OCF3 is an effective deoxyfluorination reagent for carboxylic acids. The method features simplicity, expeditiousness, high efficiency, ease of handling, good functional group tolerance, a wide range of substrates, excellent yields of products, compatibility of many amine initiators, use of environmentally friendly reagents, and effortless removal of byproducts. This reaction represents the first utilization of trifluoromethyl trifluoromethanesulfonate as a fluorination reagent.
Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis
Birrell, James A.,Desrosiers, Jean-Nicolas,Jacobsen, Eric N.
supporting information; experimental part, p. 13872 - 13875 (2011/10/09)
A highly enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful α,α-disubstituted butyrolactone products. This transformation is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride.