78077-47-1Relevant articles and documents
Synthesis and structure-activity relationship; exploration of some potent anti-cancer phenyl amidrazone derivatives
Habashneh, Almeqdad Y.,El-Abadelah, Mustafa M.,Bardaweel, Sanaa K.,Taha, Mutasem O.
, p. 468 - 477 (2018/07/25)
Background: Amidrazones have been reported to have significant anti-tumor properties against several cancer cell lines. Objectives: The current project aims to profile the structure-anticancer activity relationship of phenyl-amidrazons. Methods: Fifteen p
Metal-assisted oxidative cyclization of arylamidrazones II [1]. Novel synthesis of 1,4-diaryi[1,2,4]triazino[6,5-h]quinolines
Khanfar, Monther A.,Abu Thaher, Bassam A.,Zahra, Jalal A.,Al-Qawasmeh, Raed A.,El-Abadelah, Mustafa M.,Voelter, Wolfgang
experimental part, p. 1107 - 1111 (2009/05/30)
New model 1,2,4-triazino[6,5-h]quinolines 8a-c are prepared by oxidative cyclization of the respective N-(quinolin-8-yl)amidrazone precursors 7a - c using copper(II) chloride. Interestingly, the cyclized products 8a - c were found to be arylated at N1posi
HETEROCYCLES FROM NITRILE IMINES. PART IV. CHIRAL 4,5-DIHYDRO-1,2,4-TRIAZIN-6-ONES
El-Abadelah, Mustafa M.,Hussein, Ahmad Q.,Thaher, Bassam A.
, p. 1879 - 1895 (2007/10/02)
The reaction of nitrile imines (II) with α-amino esters (III) proceeds with no detectable racemization and constitutes a convenient synthetic route to 4,5-dihydro-1,2,4-triazin-6-ones (IV).Permangamate oxidation of heterocycles (IV) affords the corresponding 1,2,4-triazin-6-ones (V).The reaction of (II) with β-amino esters gives the respective acyclic amidrazone adducts (VI).
