780800-85-3Relevant articles and documents
Synthesis, photophysical properties and DFT studies of the pyridine-imidazole (PyIm) Cu(I) complexes: Impact of the pyridine ring functionalized by different substituents
Chai, Chaoyang,Xu, Shengxian,Wang, Jinglan,Zhao, Feng,Xia, Hongying,Wang, Yibo
, p. 34 - 40 (2019)
A series of the pyridine-imidazole (PyIm) Cu(I) complexes with different substituents (bromide (P1), methyl (P2), and phenyl (P3)) attached on the pyridine ring are synthesized and characterized. All the complexes show the typical metal-to-ligand charge transfer (MLCT) absorption in the visible region. Complex P1 with an electron-withdrawing substituent on the pyridine ring, e.g., a bromine group, shows a red shift of the emission wavelength. Conversely, an electron-donating substituent on the pyridine ring in complex P2, e.g., a methyl group, shifts the emission to longer wavelength. Similarly, complex P3 containing the extended π-conjugation system of the ligand also exhibits a red shift of the emission wavelength. All of the complexes exhibit efficient green-yellow emission in PMMA films at room temperature with emission wavelength of 547–569 nm and quantum yields of 24.8–53.0%. Meanwhile, DFT and TDDFT methods were employed to explain the photophysical properties.
1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS
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Paragraph 0691; 0693, (2020/11/30)
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The novel compounds have formula (I): (Formula (I)) or are pharmaceutically acceptable salts thereof, wherein: R1a, R1b, R1c, R1d, R1e and R1f each independently represent hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C4 cycloalkyl, or R1b and R1c together form an optionally substituted C3-C6 cycloalkyl ring, or R1d and R1e together form an optionally substituted C3-C6 cycloalkyl ring; R2 represents hydrogen or optionally substituted C1-C6 alkyl; A represents an optionally further substituted 5 to 10 membered monocyclic or bicyclic heteroaryl, heterocyclyl or aryl ring; L represents a covalent bond or linker; B represents an optionally substituted 3 to 10 membered monocyclic or bicyclic heterocyclyl, heteroaryl, cycloalkyl or aryl ring; and when -A-L-B is at position x attachment to A is via a carbon ring atom of A, and either: A cannot be triazolopyridazinyl, triazolopyridinyl, imidazotriazinyl, imidazopyrazinyl or pyrrolopyrimidinyl; or B cannot be substituted with phenoxyl; or B cannot be cyclopentyl when L is an oxygen atom.
An efficient synthetic approach towards new 5,5’-diaryl-2,2’-bipyridine-based fluorophores
Krinochkin, Alexey P.,Kopchuk, Dmitry S.,Chepchugov, Nikolay V.,Kim, Grigory A.,Kovalev, Igor S.,Rahman, Matiur,Zyryanov, Grigory V.,Majee, Adinath,Rusinov, Vladimir L.,Chupakhin, Oleg N.
, p. 1099 - 1103 (2017/05/19)
An efficient approach has been developed for the synthesis of 5,5′-diaryl-2,2′-bipyridines via their 1,2,4-triazine analogues. The notable advantages of the present method are: The possibility of varying the aromatic substituents in the positions 5 and 5′ of bipyridine core and the possibility for obtaining 2,2′-bipyridines bearing a fused cyclopentene core to increase the solubility in organic solvents. These 5,5′-diaryl-2,2′-bipyridines exhibited an intense emission in a range of ca. 422–521?nm in acetonitrile solution; depending on the nature of the aromatic substituents and the presence of annulated cyclopentene fragments. Apart from that, the significant bathochromic shifts of the both absorption and emission maxima were observed in comparison with a number of previously described similar structures. In some cases the significant increasing of the fluorescence quantum yields took place.
