78133-52-5

Basic information

• Product Name: dimethyl isoquinolin-1-ylphosphonate
• Synonyms: dimethyl isoquinolin-1-ylphosphonate
• CAS NO: 78133-52-5
• Molecular Weight: 237.195
• Mol File: 78133-52-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl isoquinolin-1-ylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl isoquinolin-1-ylphosphonate(78133-52-5)
• EPA Substance Registry System: dimethyl isoquinolin-1-ylphosphonate(78133-52-5)

Safety Data

• Hazardous Substances Data: 78133-52-5(Hazardous Substances Data)

Upstream product

• 1532-72-5 isoquinoline N-oxide 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 3297-72-1 1-phenylisoquinoline 
• 7661-38-3 1-butylisoquinoline 

Relevant articles and documents

Metal-free phosphonation of heteroarene N-oxides with trialkyl phosphite at room temperature

A new protocol is described for the conversion of heteroarene N-oxides to heteroarylphosphonates through in situ activation with bromotrichloromethane. The N-oxides of isoquinoline, quinoline, quinoxaline and 1,10-phenanthroline were fast transformed into the corresponding heteroarylphosphonates in up to 92% yield under mild conditions in the absence of solvent and metal catalysts. The good functional group tolerance, low cost, feasibility of scale up, and wide availability of reagents make this method a prominent complement to the Hirao coupling.