78317-83-6

Basic information

• Product Name: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-
• Synonyms: N-PMP-1,2,3,4-tetrahydroisoquinoline;N-p-methoxyphenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 78317-83-6
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• Mol File: 78317-83-6.mol
• Article Data: 61

Chemical Properties

• Melting Point: 91-94°C
• CAS DataBase Reference: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-(78317-83-6)
• EPA Substance Registry System: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-(78317-83-6)

Safety Data

• Hazardous Substances Data: 78317-83-6(Hazardous Substances Data)

Usage

Description

Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)is a chemical compound belonging to the isoquinoline family. It is characterized by its unique molecular structure, which features a 1,2,3,4-tetrahydroisoquinoline core with a 4-methoxyphenyl group attached at the 2-position. Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)is known for its potential applications in various chemical and pharmaceutical processes.

Uses

Used in Chemical Synthesis:
Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)is used as a reagent in the gold-catalyzed preparation of indoletetrahydroisoquinolines. This application takes advantage of the compound's unique structure and reactivity, enabling the synthesis of complex organic molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)may also find use in the pharmaceutical industry as a building block for the development of new drugs. Its unique structure and functional groups can be utilized in the design and synthesis of novel therapeutic agents, potentially leading to the discovery of new treatments for various diseases and conditions.

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 
• 119-65-3 isoquinoline 
• 38018-60-9 (E/Z)-2-bromo-4'-methoxystilbene 
• 104-94-9 4-methoxy-aniline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 356531-15-2 N-(4-methoxyphenyl)-2-bromobenzylamine 
• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 100-66-3 methoxybenzene 
• 153333-52-9 1-(2-iodoethyl)-2-(iodomethyl)benzene 
• 493-05-0 isochromane 
• 64-04-0 phenethylamine 

Downstream Products

• 850130-96-0 2-(4-methoxyphenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-15-1 1-(4-methoxyphenyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-16-2 1-(biphenyl-4-yl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-18-4 2-(4-methoxyphenyl)-1-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-20-8 1-(4-tert-butylphenyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-17-3 1-(4-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phenyl)ethanone 
• 1048958-14-0 1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1141447-85-9 1-[1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-1-isoquinolinyl]hexan-2-one 
• 1141447-88-2 2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethan-1-one 
• 1141447-90-6 2-[1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-1-isoquinolinyl]-1-p-tolylethanone 
• 1141447-82-6 1-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-propan-2-one 
• 1141447-92-8 2-[1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-1-isoquinolinyl]-1-(4-methoxyphenyl)ethanone 
• 1150587-84-0 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone 

Relevant articles and documents

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An oxidant- And catalyst-free electrooxidative cross-coupling approach to 3-tetrahydroisoquinoline substituted coumarins

A direct electrooxidative cross-dehydrogenative-coupling (CDC) reaction betweenN-aryl-tetrahydroisoquinolines and 4-hydroxycoumarins has been realized. This protocol provides a green, mild and fast method to construct 3-tetrahydroisoquinoline substituted coumarins in the absence of any catalysts and exogenous oxidants. A variety ofN-aryl-tetrahydroisoquinolines and 4-hydroxycoumarins are compatible with this transformation to give the corresponding products in moderate to excellent yields. Moreover, the results of control experiments, cyclic voltammetry experiments, and density functional theory (DFT) calculations indicated that the electrooxidative CDC reaction might involve both radical addition and nucleophilic addition processes.