78339-51-2

Basic information

• Product Name: Podophyllol
• Synonyms: Podophyllol
• CAS NO: 78339-51-2
• Molecular Formula: C₂₂H₂₆O₈
• Molecular Weight: 418.44
• Mol File: 78339-51-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Podophyllol(CAS DataBase Reference)
• NIST Chemistry Reference: Podophyllol(78339-51-2)
• EPA Substance Registry System: Podophyllol(78339-51-2)

Safety Data

• Hazardous Substances Data: 78339-51-2(Hazardous Substances Data)

Usage

Description

Podophyllol, a resin extract derived from the roots and rhizomes of the podophyllum plant, is known for its potent cytotoxic and antiviral properties. This natural compound possesses the ability to inhibit cell division and viral replication, making it a valuable asset in the medical field.

Uses

Used in Pharmaceutical Industry:
Podophyllol is used as a topical treatment for genital warts, as it effectively inhibits cell division and viral replication in the affected area. It is applied in the form of a cream or solution, and it is crucial to follow the precise instructions for application to avoid contact with healthy skin.
Used in Antiviral Applications:
Due to its antiviral properties, podophyllol is utilized in the development of antiviral medications, targeting the inhibition of viral replication and providing relief to patients suffering from viral infections.

Upstream product

• 518-28-5 podofilox 
• 139955-57-0 methyl podophyllotoxinate diacetate 

Downstream Products

• 62287-47-2 neoanhydropodophyllol 
• 256331-34-7 6-[(1R,2S,3S)-4-Ethoxycarbonyloxy-2-ethoxycarbonyloxymethyl-3-methanesulfonyloxy-1-(3,4,5-trimethoxy-phenyl)-butyl]-benzo[1,3]dioxole-5-carboxylic acid 
• 256331-33-6 Methanesulfonic acid (1S,2S,3R)-1,2-bis-ethoxycarbonyloxymethyl-3-(6-formyl-benzo[1,3]dioxol-5-yl)-3-(3,4,5-trimethoxy-phenyl)-propyl ester 
• 256331-31-4 Carbonic acid (2R,3S,4R)-3-ethoxycarbonyloxymethyl-2-hydroxy-4-(6-hydroxymethyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-30-3 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-2-hydroxy-4-(6-hydroxymethyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-36-9 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-iodo-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-42-7 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-2-hydroxy-4-(6-methyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-35-8 Carbonic acid (2R,3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-37-0 Carbonic acid (6R,7R,8R)-6-ethoxycarbonyloxymethyl-8-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]quinolin-7-ylmethyl ester ethyl ester 
• 256331-29-0 Carbonic acid (3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-oxo-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 683805-37-0 [(4aR,5S,6S,11bR)-6-(2-Chloro-3,4,5-trimethoxy-phenyl)-2-phenyl-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthren-5-yl]-acetic acid 
• 683805-40-5 2-[(4aR,5R,6R,11bR)-2-Phenyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthren-5-yl]-acetamide 
• 683805-38-1 Methanesulfonic acid (4aR,5R,6R,11bR)-2-phenyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthren-5-ylmethyl ester 
• 683805-34-7 2-[(4aR,5S,6R,11bR)-2-Phenyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthren-5-yl]-ethanol 

Relevant articles and documents

Synthesis of podophyllotoxin analogues: δ-lactone-containing picropodophyllin, podophyllotoxin and 4′-demethyl-epipodophyllotoxin derivatives

Non-epimerizable cis and trans δ-lactone analogues of podophyllotoxin have been prepared. Thus the synthesis of the cis isomer 4 has been achieved in 8 steps and 4% overall yield from podophyllotoxin 1 via the reduction of the γ lactone ring into the tran

Synthesis of (-)-4-aza-4-deoxypodophyllotoxin from (-)-podophyllotoxin

(-)-4-Aza-4-deoxypodophyllotoxin (4) was synthesized from (-)-podophyllotoxin (1) through C-ring cleavage, Curtius rearrangement and intramolecular N-alkylation. Analogue 4 showed potent cytotoxicity against P388 leukemia cells.

PREPARATION OF TRIOLS AND ETHERS RELATED TO PODOPHYLLOTOXIN

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