78358-12-0

Basic information

• Product Name: methanesulfonic acid 2-methoxy-benzyl ester
• Synonyms: methanesulfonic acid 2-methoxy-benzyl ester
• CAS NO: 78358-12-0
• Molecular Weight: 216.258
• Mol File: 78358-12-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 2-methoxy-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 2-methoxy-benzyl ester(78358-12-0)
• EPA Substance Registry System: methanesulfonic acid 2-methoxy-benzyl ester(78358-12-0)

Safety Data

• Hazardous Substances Data: 78358-12-0(Hazardous Substances Data)

Upstream product

• 612-16-8 (2-methoxyphenyl)methanol 
• 124-63-0 methanesulfonyl chloride 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 221533-70-6 4-(2-methoxybenzyl)cyclohexanone 
• 221533-11-5 8-(2-methoxybenzylidene)-1,4-dioxaspiro<4.5>decane 
• 1025875-17-5 8-(2-methoxy-benzyl)-1,4-dioxa-spiro[4.5]decane 
• 300823-47-6 1-(azidomethyl)-2-methoxybenzene 
• 1410807-69-0 4-(2-methoxyphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside 
• 1410807-91-8 4-(2-methoxyphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl β-d-glucopyranoside 
• 1410807-23-6 1,2-dihydro-4-(2-methoxyphenylmethyl)-5-isopropyl-3H-pyrazol-3-one 
• 1410806-90-4 C₁₅H₂₀O₄ 

Relevant articles and documents

Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry

The over-expression of aminopeptidase N on diverse malignant cells is associated with the tumor angiogenesis and metastasis. In this report, one new series of leucine ureido derivatives containing the triazole moiety was designed, synthesized and evaluated as APN inhibitors. Among them, compound 13v showed the best APN inhibition with an IC50 value of 0.089 ± 0.007 μM, which was two orders of magnitude lower than that of bestatin (IC50 = 9.4 ± 0.5 μM). Compound 13v also showed dose-dependent anti-angiogenesis activities. Even at the lower concentration (10 μM), compound 13v presented similar anti-angiogenesis activity compared with bestatin at 100 μM in both the human umbilical vein endothelial cells (HUVECs) capillary tube formation assay and the rat thoracic aorta rings test. Moreover, compared with bestatin, 13v exhibited comparable, if not better in vivo anti-metastasis activity in a mouse H22 pulmonary metastasis model.

A metal-free catalytic system for the oxidation of benzylic methylenes and primary amines under solvent-free conditions

Iodine-pyridine-tert-butylhydroperoxide is developed as a green and efficient catalytic system for the oxidation of benzylic methylenes to ketones and primary amines to nitriles. The reaction conditions are quite mild and environmentally benign, no transition metals, organic solvents or hazard reagents being needed. The oxidation of benzylic methylenes gave the corresponding ketones in excellent yields with complete chemoselectivity, while the oxidation of primary amines was complete in several minutes, affording various nitriles in moderate to good yields.