78420-14-1

Basic information

• Product Name: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid
• Synonyms: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid;(4S)-3-[(3S)-3-Cyclohexyl-3-hydroxypropyl]-2,5-dioxo-4-imidazolidineheptanoic acid
• CAS NO: 78420-14-1
• Molecular Formula: C₁₉H₃₂N₂O₅
• Molecular Weight: 368.46778
• EINECS: 278-904-1
• Mol File: 78420-14-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid(78420-14-1)
• EPA Substance Registry System: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid(78420-14-1)

Safety Data

• Hazardous Substances Data: 78420-14-1(Hazardous Substances Data)

Usage

Description

[S-(R,R)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid, commonly known as Ramipril, is a pharmaceutical compound that belongs to the class of angiotensin-converting enzyme (ACE) inhibitors. It is characterized by its ability to relax blood vessels and reduce the workload on the heart, making it a valuable treatment for various cardiovascular conditions.

Uses

Used in Pharmaceutical Industry:
Ramipril is used as an ACE inhibitor for the treatment of high blood pressure, heart failure, and diabetic kidney disease. Its application is based on its ability to relax blood vessels and reduce the workload on the heart, which helps in managing these conditions effectively.
Used in Cardiovascular Applications:
In the cardiovascular field, Ramipril is used to improve blood flow and reduce the strain on the heart. This is achieved by inhibiting the angiotensin-converting enzyme, which in turn lowers blood pressure and decreases the risk of heart-related complications.

Upstream product

• 72880-74-1 diethyl (S)-2-aminononanedioate 
• 72880-73-0 (S)-2-aminononanedioic acid 9-ethyl ester 
• 72814-33-6 2-aminononanedioic acid 9-ethyl ester 
• 77448-06-7 diethyl (2S)-2-(3-cyclohexyl-3-oxopropylamino)nonanedioate 
• 65705-50-2 diethyl 2-aminononanedioate 
• 2177-34-6 1-cyclohexylprop-2-en-1-one 
• 74-90-8 hydrogen cyanide 
• 77448-08-9 diethyl (2S)-2-<(3S)-3-cyclohexyl-3-hydroxypropylamino>nonanedioate 
• 590-28-3 potassium cyanate 
• 73487-97-5 (+/-)-diethyl 2-(3-cyclohexyl-3-hydroxypropylamino)nonanedioate hydrochloride 
• 73487-97-5 (+/-)-diethyl 2-(3-cyclohexyl-3-hydroxypropylamino)nonanedioate hydrochloride 

Downstream Products

• 78420-16-3 (5R)-5-(6-carboxyhexyl)-1-<(3S)-3-cyclohexyl-3-hydroxypropyl>hydantoin 
• 73490-09-2 (+/-)-3-(3-cyclohexyl-3-oxopropyl)-2,5-dioxo-4-imidazolidineheptanoic acid 

Relevant articles and documents

Heterocyclic Prostaglandin Analogues. Part 3. The Relationship of Configuration to Biological Activity for Some Hydantoin Prostanglandin Analogues

The enantiomers of the two diastereomers of 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin have been synthesised.Potent inhibition of platelet aggregation in this series is associated with the configuration corresponding to that in the natural inhibitors, such as prostaglandins E1 and D2.