786600-48-4 Usage
General Description
2-Amino-1-(3,4-dimethylphenyl)ethanol, also known as 3,4-DiMPEA, is a chemical compound with the molecular formula C10H15NO. It is a secondary amine and a phenol derivative, containing an amino group and a hydroxyl group attached to a central carbon atom. 2-amino-1-(3,4-dimethylphenyl)ethanol is commonly used as a precursor in the synthesis of various pharmaceuticals and organic compounds. It may also have potential applications in the field of medicinal chemistry and drug development due to its structural features. Additionally, 2-amino-1-(3,4-dimethylphenyl)ethanol has been studied for its potential biological activities and therapeutic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 786600-48-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,6,6,0 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 786600-48:
(8*7)+(7*8)+(6*6)+(5*6)+(4*0)+(3*0)+(2*4)+(1*8)=194
194 % 10 = 4
So 786600-48-4 is a valid CAS Registry Number.
InChI:InChI=1S/C10H15NO/c1-7-3-4-9(5-8(7)2)10(12)6-11/h3-5,10,12H,6,11H2,1-2H3
786600-48-4Relevant articles and documents
Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides
Taban, Ismail M.,Zhu, Jinge,DeLuca, Hector F.,Simons, Claire
supporting information, p. 4076 - 4087 (2017/07/05)
CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D). A series of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides have been synthesised using an efficient synthetic route and shown to be potent inhibitors of CYP24A1 (IC50 0.11–0.35?μM) compared with the standard ketoconazole. Molecular modelling using our CYP24A1 homology model showed the inhibitors to fill the hydrophobic binding site, forming key transition metal interaction between the imidazole nitrogen and the haem Fe3+ and multiple interactions with the active site amino acid residues.
