78904-45-7 Usage
Description
1-(2,4,6-Trimethoxyphenyl)-2-nitropropene, with the molecular formula C12H15NO5, is a yellow liquid chemical compound belonging to the class of nitroalkenes. It is characterized by the presence of a nitro group and an alkene functional group, which contribute to its reactivity and make it a valuable intermediate in organic synthesis. This versatile compound can participate in a wide range of chemical reactions, making it an important asset in the field of organic chemistry.
Uses
Used in Pharmaceutical Synthesis:
1-(2,4,6-Trimethoxyphenyl)-2-nitropropene is used as a key intermediate in the synthesis of various pharmaceuticals. Its reactivity and functional groups allow for the creation of a diverse array of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Organic Synthesis:
In the field of organic chemistry, 1-(2,4,6-Trimethoxyphenyl)-2-nitropropene serves as a versatile building block for the creation of a multitude of organic compounds. Its ability to undergo various chemical reactions makes it a valuable asset in the synthesis of complex molecules and the advancement of organic chemistry research.
Used in Chemical Research:
1-(2,4,6-Trimethoxyphenyl)-2-nitropropene is also utilized in chemical research to study the properties and reactions of nitroalkenes. This helps scientists better understand the behavior of these compounds and develop new methods for their synthesis and application in various industries.
Used in the Chemical Industry:
The chemical industry benefits from the use of 1-(2,4,6-Trimethoxyphenyl)-2-nitropropene as a starting material for the production of various specialty chemicals. Its reactivity and functional groups enable the creation of a wide range of products, from dyes to additives, that serve various purposes in different sectors.
Check Digit Verification of cas no
The CAS Registry Mumber 78904-45-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,9,0 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 78904-45:
(7*7)+(6*8)+(5*9)+(4*0)+(3*4)+(2*4)+(1*5)=167
167 % 10 = 7
So 78904-45-7 is a valid CAS Registry Number.
78904-45-7Relevant articles and documents
Sulfur-substituted α-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling
Gallardo-Godoy, Alejandra,Fierro, Angélica,McLean, Thomas H.,Castillo, Mariano,Cassels, Bruce K.,Reyes-Parada, Miguel,Nichols, David E.
, p. 2407 - 2419 (2007/10/03)
A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-α methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Several compounds showed potent and selective MAO-A inhibitory activity (IC50 in the submicromolar range) but none showed appreciable activity toward MAO-B. A three-dimensional quantitative structure-activity relationship study for MAO-A inhibition was performed on the series using comparative molecular field analysis (CoMFA). The resulting model gave a cross-validated q2 of 0.72 and showed that in this series of compounds steric properties of the substituents were more important than electrostatic effects. Molecular modeling based on the recently published crystal structure of inhibitor-bound MAO-A provided detailed evidence for specific interactions of the ligands with the enzyme, supported by previous references and consistent with results from the CoMFA. On the basis of these results, structural determinants for selectivity of substituted amphetamines for MAO-A are discussed.
The six trimethoxyphenylisopropylamines (trimethoxyamphetamines).
Shulgin
, p. 445 - 446 (2007/10/05)
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