79463-77-7 Usage
Description
Diphenyl N-cyanocarbonimidate is an organic compound with the chemical formula (C6H5)2N=C=N-C≡N. It is a versatile intermediate in organic synthesis and has been utilized in the preparation of various chemical compounds.
Uses
Used in Organic Synthesis:
Diphenyl N-cyanocarbonimidate is used as a key intermediate for the synthesis of N-substituted 2-amino-4H-3,1-benzoxazines, which are important building blocks in the development of pharmaceuticals, agrochemicals, and other specialty chemicals. These benzoxazines exhibit a wide range of biological activities, including antimicrobial, antiviral, and anticancer properties.
Additionally, Diphenyl N-cyanocarbonimidate is used in the preparation of cyanoguanidine derivatives, which are valuable compounds in the synthesis of various heterocyclic compounds, such as triazoles, tetrazoles, and imidazolines. These heterocyclic compounds have found applications in pharmaceuticals, agrochemicals, and materials science.
Furthermore, Diphenyl N-cyanocarbonimidate is employed in the synthesis of oxadiazoles, a class of five-membered heterocyclic compounds containing two oxygen atoms and one nitrogen atom. Oxadiazoles have been extensively studied for their potential applications in various fields, such as pharmaceuticals, agrochemicals, dyes, and materials science, due to their unique chemical and physical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 79463-77-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,4,6 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 79463-77:
(7*7)+(6*9)+(5*4)+(4*6)+(3*3)+(2*7)+(1*7)=177
177 % 10 = 7
So 79463-77-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H10N2O2/c15-11-16-14(17-12-7-3-1-4-8-12)18-13-9-5-2-6-10-13/h1-10H
79463-77-7Relevant articles and documents
Novel Gonadotropin-Releasing Hormone Antagonists: Peptides Incorporating Modified Nω-Cyanoguanidino Moieties
Theobald, Paula,Porter, John,Rivier, Catherine,Corrigan, Anne,Hook, William,et al.
, p. 2395 - 2402 (2007/10/02)
In order to minimize the deleterious effects of histamine release resulting from the administration to rats and humans of some potent gonadotropin-releasing hormone (GnRH) antagonists, various arginine residues were replaced with the less basic Nω-cyano-Nω'-alkyl- or -arylhomoarginine, -arginine, or -p-aminophenylalanine and Nω-triazolyllysine, -ornithine or -p-aminophenylalanine residues in active analogues.These novel analogues were synthesized on a solid-phase support via a two-step modification of the Nω-NH2 of lysine, ornithine, or p-aminophenylalanineresidues in otherwise protected resin bound peptides.Most analogues were tested in the rat antiovulatory assay (AOA) and three in vitro assays: a pituitary cell culture assay, a binding assay to pituitary cell membranes, and a histamine release assay.Introduction of the cyanoguanidino and Nω-triazolyl moieties into GnRH analogues yielded several water-soluble antagonists which showed a desirable therapeutic ratio (low histamine release activity to high in vivo potency).Among them, "Azaline" (10, 1,DCpa2,DPal3,Lys5(atz),DLys6(atz),ILys8,DAla10>GnRH), inhibited ovulation in the rat by 90percent at 2 μg/rat with an ED50 in the in vitro histamine release assay comparable to that of GnRH itself.