797-64-8

Basic information

• Product Name: (-)-NORGESTREL 98
• Synonyms: 18,19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(8-alpha,9-beta,10-alp;dextronorgestrel;(-)-NORGESTREL 98;(-)-NORGESTREL 98%;extronorgestrel;l-norgestre1;(8α,9β,10α,13α,14β)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one;(8S,9R,10S,13R,14R,17S)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS NO: 797-64-8
• Molecular Formula: C₂₁H₂₈O₂
• Molecular Weight: 312.44582
• EINECS: 229-433-5
• Mol File: 797-64-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 239-241 °C(lit.)
• Boiling Point: 392.36°C (rough estimate)
• Appearance: /
• Density: 1.0697 (rough estimate)
• Refractive Index: 1.4900 (estimate)
• CAS DataBase Reference: (-)-NORGESTREL 98(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-NORGESTREL 98(797-64-8)
• EPA Substance Registry System: (-)-NORGESTREL 98(797-64-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: JF8259000
• Hazardous Substances Data: 797-64-8(Hazardous Substances Data)

Usage

Description

(-)-NORGESTREL 98, also known as L(+)-Norgestrel, is a bioactive enantiomer of the progestational and ovulation inhibiting steroid. It is a levorotatory compound with progestogen properties, commonly used in oral contraceptives.
Used in Pharmaceutical Industry:
(-)-NORGESTREL 98 is used as a progestogen in oral contraceptives for its ability to inhibit ovulation and provide progestational support, contributing to effective birth control.

Safety Profile

Moderately toxic byintraperitoneal route. Human male reproductive effects byingestion: disorders of spermatogenesis and theandrogenic endocrine system, impotence and othereffects. Human female reproductive effects by severalroutes: changes in the ute

InChI:InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21+/m0/s1

Upstream product

• 2322-77-2 dl-3-methoxy-13β-ethylgona-2,5(10)-dien-17-one 
• 74-86-2 acetylene 
• 23759-68-4 (3aS,5aS,6R,9aR,9bS)-3a-Ethyl-6-(3-oxo-butyl)-decahydro-cyclopenta[a]naphthalene-3,7-dione 
• 23855-42-7 (5R,8R,9S,10R,13S,14S)-13-Ethyl-5-hydroxy-3-methyl-tetradecahydro-4-oxa-cyclopenta[a]phenanthren-17-one 
• 101025-90-5 Acetic acid 2-ethyl-3-vinyl-cyclopent-1-enyl ester 
• 75863-25-1 2-Trimethylsilyl-1-(4-methoxy-2-methylphenyl)prop-2-en-1-on 
• 1038-28-4 dl-3-methoxy-13β-ethylgona-2,5(10)-dien-17β-ol 
• 848-05-5 (+/-)-13-Ethyl-3-methoxygona-1,3,5⁽¹⁰⁾,9⁽¹¹⁾-tetraen-17-on 
• 21800-83-9 (+/-)-13β-Ethylgon-4-ene-3,17-dione 
• 799-43-9 13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol 

Downstream Products

• 6544-68-9 13β-ethyl-3-hydroxygona-1,3,5(10)-trien-17-one 
• 797-58-0 DL-17β-Hydroxy-13β.17α-diethyl-gon-4-en-3-on 
• 14012-72-7 13β-ethyl-18,19-dinor-17α-pregna-1,3,5(10)-trien-20-yne-3,17β-diol 

Relevant articles and documents

Preparation method of levonorgestrel

The invention discloses a preparation method of levonorgestrel, and belongs to the technical field of medicine preparation and processing. According to the method, 18-methylestra-2,5(10)-diene-3-methoxy-17-ketone is used as an initial raw material, and the levonorgestrel disclosed by the invention is prepared by virtue of two steps of ethynylation and hydrolysis. According to the preparation method of the levonorgestrel, the defects of a traditional process are overcome and reaction conditions are mild; the method is high in overall conversion rate, easy and convenient to operate, suitable forindustrial production and wide in market prospect.

Synthesis of 13-alkyl-gon-4-ones

The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.