79868-87-4Relevant articles and documents
A VERSATILE SYNTHESIS OF ARYLACETONES FROM ARYL HALIDES AND ACETYLACETONATE
Sugai, Saburo,Ikawa, Hiroshi,Okazaki, Tokuji,Akaboshi, Sanya,Ikegami, Shiro
, p. 597 - 600 (1982)
Reaction of aryl halides with sodium or potassium acetylacetonate in the presence of a copper catalyst affords directly arylacetones resulted from deacetylation of initially formed 3-arylacetylacetones in good yields.
Alternative synthesis of 2-arylpropanoic acids from enolate and aryl halides
Ferrayoli, Carlos G.,Palacios, Sara M.,Alonso, Ruben A.
, p. 1635 - 1638 (2007/10/02)
Arylpropanoic acids, a type of non-steroidal antiinflammatory drug, have been prepared in liquid ammonia by photo-radical nucleophilic substitution of halogenoarenes with sodium N,N-dimethylacetamide enolate followed by methylation and hydrolysis.Rapid substitution occured in many cases with good to excellent yields of arylpropanoic acids.The title compounds have also been prepared by arylation of sodium acetone enolate with methylation and oxidation in a haloform reaction.
