80054-97-3

Basic information

• Product Name: (E)-3-phenyl-2-propenoic acid 2,2,2-trifluoroethyl ester
• Synonyms: (E)-3-phenyl-2-propenoic acid 2,2,2-trifluoroethyl ester
• CAS NO: 80054-97-3
• Molecular Weight: 230.186
• Mol File: 80054-97-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-3-phenyl-2-propenoic acid 2,2,2-trifluoroethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-phenyl-2-propenoic acid 2,2,2-trifluoroethyl ester(80054-97-3)
• EPA Substance Registry System: (E)-3-phenyl-2-propenoic acid 2,2,2-trifluoroethyl ester(80054-97-3)

Safety Data

• Hazardous Substances Data: 80054-97-3(Hazardous Substances Data)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 140-10-3 (E)-3-phenylacrylic acid 
• 1407150-78-0 C₂₇H₂₈N₂O₂ 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 

Downstream Products

• 14399-14-5 threo-(1R,2R)-1-(4-nitrophenyl)-2-(dichloroacetamido)-1,3-propanediol 3-cinnamate 
• 52392-64-0 (E)-3-(phenyl)acrylic acid butyl ester 
• 1178910-36-5 C₁₉H₂₁F₃O₂Si 
• 23522-66-9 2,2,2-trifluoroethyl 3-phenylpropanoate 
• 1039768-40-5 (S)-3-(dimethylphenylsilyl)-3-phenylpropanoic acid 2,2,2-trifluoroethyl ester 

Relevant articles and documents

Aromatic carboxylic acid trifluoro ethyl ester compound and its preparation method (by machine translation)

Aromatic carboxylic acid trifluoro ethyl ester compound and its preparation method. The present invention provides a kind of aromatic carboxylic acid trifluoroacetate ester compound and its preparation method, the method is that the aromatic carboxylic acid and nitrous acid tert-butyl and 2, 2, 2 - trifluoro ethylamine one-pot synthesis after reaction, to obtain the carboxylic acid trifluoroacetate ester compound. The method is simple in operation, mild reaction conditions, low cost, few by-products, high yield, can be aromatic carboxylic acid trifluoroacetate ester compound, not limited by substrate, in order to establish aromatic carboxylic acid trifluoroacetate ester compound library, for drug screening and new drug synthesis of the raw material sources. (by machine translation)

A facile and efficient synthesis of 2,2,2-trifluoroethyl 2-[(E)-N-phenylcinnamamido]-2-phenylacetates in trifluoroethanol via sequential Ugi four-component reaction/esterification

We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields.