80418-25-3

Basic information

• Product Name: Notoginsenoside R2
• Synonyms: Notoginsenoside R2;20(S)-Notoginsenoside R2;Ginsenoside Ng-R2;S-Notoginsenoside R2
• CAS NO: 80418-25-3
• Molecular Formula: C₄₁H₇₀O₁₃
• Molecular Weight: 770.9867
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 80418-25-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 878.731°C at 760 mmHg
• Flash Point: 485.239°C
• Appearance: /
• Density: 1.31±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: Notoginsenoside R2(CAS DataBase Reference)
• NIST Chemistry Reference: Notoginsenoside R2(80418-25-3)
• EPA Substance Registry System: Notoginsenoside R2(80418-25-3)

Safety Data

• Hazardous Substances Data: 80418-25-3(Hazardous Substances Data)

Usage

Description

Notoginsenoside R2, also known as S-Notoginsenoside R2, is a naturally occurring active component extracted from the traditional Chinese medicinal plant Panax notoginseng, commonly known as Sanqi or Tianqi. It is a saponin glycoside with a unique chemical structure and possesses a wide range of pharmacological properties, making it a valuable compound for various therapeutic applications.

Uses

Used in Traditional Chinese Medicine:
Notoginsenoside R2 is used as a folk medicine for its diverse range of health benefits, including immunomodulatory, cardioprotective, hepatoprotective, anti-diabetic, and anticancer activities. Its multifaceted therapeutic potential has been recognized and utilized in traditional Chinese medicine for centuries.
Used in Immunomodulation:
Notoginsenoside R2 is used as an immunomodulatory agent to regulate the immune system and enhance the body's natural defense mechanisms against infections and diseases. Its immunomodulatory properties make it a promising candidate for the treatment of various immune-related disorders.
Used in Cardiovascular Protection:
As a cardioprotective agent, Notoginsenoside R2 is used to protect the heart and improve cardiovascular health. It has been shown to possess antiplatelet, anticoagulant, and vasodilatory effects, which contribute to the prevention and treatment of various cardiovascular diseases.
Used in Liver Protection:
Notoginsenoside R2 is used as a hepatoprotective agent to safeguard the liver from damage and promote its health. Its hepatoprotective properties make it a potential therapeutic option for the treatment of liver diseases, including hepatitis and liver fibrosis.
Used in Diabetes Management:
As an anti-diabetic agent, Notoginsenoside R2 is used to manage and treat diabetes by improving insulin sensitivity and glucose metabolism. Its anti-diabetic effects make it a valuable compound for the development of novel therapeutic strategies for diabetes management.
Used in Anticancer Therapy:
Notoginsenoside R2 is used as an anticancer agent to inhibit the growth and proliferation of cancer cells. Its anticancer properties have been attributed to its ability to modulate various signaling pathways and induce apoptosis in cancer cells, making it a promising candidate for the development of novel cancer therapies.

InChI:InChI=1/C41H70O13/c1-20(2)10-9-13-41(8,50)21-11-15-39(6)28(21)22(43)16-26-38(5)14-12-27(45)37(3,4)34(38)24(17-40(26,39)7)52-36-33(31(48)30(47)25(18-42)53-36)54-35-32(49)29(46)23(44)19-51-35/h10,21-36,42-50H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26+,27-,28-,29-,30+,31-,32+,33+,34-,35-,36+,38+,39+,40+,41-/m0/s1

Upstream product

• 80418-24-2 notoginsenoside R₁ 

Downstream Products

• 80952-71-2 ginsenoside Rh₁ 

Relevant articles and documents

Dammarane-saponins of Sanchi-Ginseng, roots of Panax notoginseng (Burk.) F.H. Chen (Araliaceae): Structures of new saponins, notoginsenosides-R1 and -R2, and identification of ginsenosides-Rg2 and -Rh1

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