809274-63-3Relevant articles and documents
Synthesis of Multibromo-Substituted Quinolines by NBS-Mediated Cascade Electrophilic Bromination/Cyclization of N -(3-Phenylprop-2-ynyl)anilines
Deng, Si,Ouyang, Wenliang,Bai, Jiang,Song, Xian-Rong,Yang, Ruchun,Xiao, Qiang
, p. 2469 - 2476 (2021)
A new and convenient protocol is presented here for the synthesis of 3,6,8-tribromoquinolines via cascade cyclization of N -(3-phenylprop-2-ynyl)anilines employing N -bromosuccinimide as an electrophile. The metal-free process is carried out under mild conditions and is compatible with a variety of substituents. The Sonogashira coupling reaction regioselectively occurs at position C-6 of the obtained products.
Heterocyclic Iodoniums for the Assembly of Oxygen-Bridged Polycyclic Heteroarenes with Water as the Oxygen Source
Zhu, Daqian,Wu, Zhouming,Luo, Bingling,Du, Yongliang,Liu, Panpan,Chen, Yunyun,Hu, Yumin,Huang, Peng,Wen, Shijun
supporting information, p. 4815 - 4818 (2018/08/24)
A diverse set of novel heterocyclic iodoniums was synthesized for the first time. The reactions of these unique iodoniums with environmentally benign water as the oxygen source provided structurally complex oxygen-incorporated heteropolycycles that are essential motifs in natural products and biologically active compounds. The transformation only required low-cost copper acetate. Further derivatization of the obtained polycycles expanded the structural diversity, which is important in the building of chemical libraries for drug discovery.
Synthesis of quinolines by electrophilic cyclization of n-(2- alkynyl)anilines: 3-iodo-4-phenylquinoline
Chen, Yu,Dubrovskiy, Anton,Larock, Richard C.
, p. 294 - 306 (2014/04/17)
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