80960-26-5

Basic information

• Product Name: 2,2-dihydroxy-4-nitro-1H-indene-1,3(2H)-dione
• Synonyms: 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy-4-nitro-
• CAS NO: 80960-26-5
• Molecular Formula: C₉H₅NO₆
• Molecular Weight: 223.1391
• Mol File: 80960-26-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 564.3°C at 760 mmHg
• Flash Point: 252.3°C
• Density: 1.927g/cm³
• Vapor Pressure: 1.42E-13mmHg at 25°C
• Refractive Index: 1.774
• CAS DataBase Reference: 2,2-dihydroxy-4-nitro-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dihydroxy-4-nitro-1H-indene-1,3(2H)-dione(80960-26-5)
• EPA Substance Registry System: 2,2-dihydroxy-4-nitro-1H-indene-1,3(2H)-dione(80960-26-5)

Safety Data

• Hazardous Substances Data: 80960-26-5(Hazardous Substances Data)

Upstream product

• 39199-63-8 4-nitroindan-1,3-dione-2-carboxylic acid ethyl ester 
• 641-70-3 3-nitrophthalic acid anhydride 
• 603-11-2 3-nitrophthalic acid 
• 24623-25-4 4-nitro-2,3-dihydro-1H-inden-1-one 
• 4535-07-3 4-nitro-2,3-dihydro-1H-indene-1,3-dione 

Downstream Products

• 1416232-06-8 1-(benzylamino)-4b,9b-dihydroxy-7-isopropyl-4bH-indeno[1,2-b]benzofuran-10(9bH)-one 
• 1416258-22-4 4-amino-2-hydroxy-2-(4-isopropyl-2-methoxyphenyl)-2H-inden-1,3-dione 
• 1416258-20-2 2-azido-2-(4-isopropyl-2-methoxyphenyl)-4-nitro-2H-inden-1,3-dione 
• 1416258-19-9 2-chloro-2-(4-isopropyl-2-methoxyphenyl)-4-nitro-2H-inden-1,3-dione 

Relevant articles and documents

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion

Ninhydrins show extensive application in organic chemistry and agriculture whereas they have been poorly investigated as bioactive molecules for medicinal chemistry purposes. A series of ninhydrin derivatives was here investigated for the inhibition of human carbonic anhydrases (CAs, EC 4.2.1.1), based on earlier evidence that gem diols are able to coordinate the metal ion from the CA active site. Ninhydrins demonstrated a micromolar inhibitory action against CA I and IX (KIs in the range 0.57–68.2 μM) and up to a nanomolar efficacy against CA II and VII (KIs in the range 0.025–78.2 μM), validated isoforms as targets in several CNS-related diseases. CA IV was instead weakly or poorly inhibited. A computational protocol based on docking, MM-GBSA and metadynamics calculations was used to elucidate the putative binding mode of this type of inhibitors to CA II and CA VII. The findings of this study testify that such pharmacologically underestimated ligands may represent interesting lead compounds for the development of CA inhibitors possessing an innovative mechanism of action, i.e., mono- or bis-coordination to the zinc ion through the diol moiety.

1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT

The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. Th