81037-04-9Relevant articles and documents
Improved robust method for preparing optically active 3-alkyl-3-phenyl-1,4- dioxane-2,5-diones; A promising new chiral template
Nagase, Ryohei,Iida, Yuuki,Sugi, Mikiko,Misaki, Tomonori,Tanabe, Yoo
experimental part, p. 3670 - 3674 (2009/07/25)
A robust method for preparing (3S)-3-alkyl-3-phenyl-1,4-dioxane-2,5-diones was developed using an improved cyclocondensation reaction between (S)-α-alkylmandelic acids and 2-bromocarbonyl halides. Subtle differences in the reaction conditions, including separate additions of triethylamine, significantly increased the yield compared with Schollkopf s original method. Georg Thieme Verlag Stuttgart · New York.
Process for preparing optically active α-hydroxy acids and derivatives thereof
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Page/Page column 20, (2008/06/13)
The present invention provides a process for preparing optically active α-hydroxy acids and derivatives thereof by subjecting the alkylated 1,3-dioxolanones of formula (IV) wherein R1and R2are the same or different and are each independently H or C1-6alkyl; R5is H, C1-16alkyl, or unsubstituted or substituted phenyl; and R6is C1-8alkyl, C2-7alkenyl or unsubstituted or substituted benzyl, to either alcoholysis or hydrolysis, in which the alkylated 1,3-dioxolanones are obtained by using 10-camphorsulfonamide as a chiral auxiliary.
Enantioselective synthesis of α-hydroxy acids employing (1S)-(+)-N,N-diisopropyl-10-camphorsulfonamide as chiral auxiliary
Chang, Jia-Wen,Jang, Der-Pin,Uang, Biing-Jiun,Liao, Fen-Ling,Wang, Sue-Lein
, p. 2061 - 2063 (2008/02/09)
matrix presented I R1=H, Me, Ph II (>98 de.) III Lewis acid (BF3·-OEt2) catalyzed condensation of dimethoxy acetal 2 with α-hydroxy acids produces chiral 1,3-dioxolanones I. The enolates derived from these compounds underg