81187-93-1

Basic information

• Product Name: 2H-Pyrrol-2-one, 4-(4-chlorophenyl)-1,5-dihydro-
• Synonyms: 4-(4-chlorophenyl)-1H-pyrrol-2(5H)-one
• CAS NO: 81187-93-1
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Mol File: 81187-93-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 214-216 °C(Solv: acetone (67-64-1))
• Boiling Point: 401.6±45.0 °C(Predicted)
• Density: 1.302±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2H-Pyrrol-2-one, 4-(4-chlorophenyl)-1,5-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrrol-2-one, 4-(4-chlorophenyl)-1,5-dihydro-(81187-93-1)
• EPA Substance Registry System: 2H-Pyrrol-2-one, 4-(4-chlorophenyl)-1,5-dihydro-(81187-93-1)

Safety Data

• Hazardous Substances Data: 81187-93-1(Hazardous Substances Data)

Upstream product

• 114566-93-7 ethyl 4-bromo-3-(4-chlorophenyl)-2-butenoate 
• 99-91-2 para-chloroacetophenone 
• 81187-86-2 ethyl 3-(4-chlorophenyl)-2-butenoate 
• 81187-90-8 (Z)-4-Bromo-3-(4-chloro-phenyl)-but-2-enoic acid 
• 81187-89-5 (E)-3-(4-chlorophenyl)but-2-enoic acid 
• 21133-98-2 ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate 
• 928215-97-8 4-(4-chlorophenyl)-2-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 81187-91-9 (Z)-4-amino-3-(4-chlorophenyl)but-2-enoic acid 

Downstream Products

• 22518-27-0 4-(4-chlorophenyl)pyrrolidin-2-one 
• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid 

Relevant articles and documents

Dihydropyrrolones as bacterial quorum sensing inhibitors

Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS), which is an intercellular communication system mediated by the binding of signaling molecules to QS receptors such as LasR. In this study, a range of dihydropyrrolone (DHP) analogues were synthesized via the lactone-lactam conversion of lactone intermediates. The synthesized compounds were tested for their ability to inhibit QS, biofilm formation and bacterial growth of Pseudomonas aeruginosa. The compounds were also docked into a LasR crystal structure to rationalize the observed structure-activity relationships. The most active compound identified in this study was compound 9i, which showed 63.1% QS inhibition of at 31.25 μM and 60% biofilm reduction at 250 μM with only moderate toxicity towards bacterial cell growth.

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh

Synthesis of analogues of GABA. VIII. (Z)- and (E)-4-amino-3-(4-chlorophenyl)but-2-enoic acids as unsaturated baclofen derivatives

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