81203-57-8 Usage
Description
1,9-Heptadecadiene-4,6-diyn-3-ol, (3S,9Z)is a synthetic organic compound with the molecular formula C17H24O2. It is characterized by the presence of two triple bonds and a hydroxyl group, which contribute to its unique chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
1,9-Heptadecadiene-4,6-diyn-3-ol, (3S,9Z)is used as a key intermediate in the synthesis of anti-tumor agents, such as Panaxytriol and Falcarinol. These compounds have demonstrated potential anti-cancer properties, making them valuable in the development of new cancer treatments.
Used in Aromatase Inhibitor Synthesis:
1,9-Heptadecadiene-4,6-diyn-3-ol, (3S,9Z)is also used in the synthesis of aromatase inhibitors, which are important in the treatment of hormone-dependent cancers, particularly breast and ovarian cancers. Aromatase inhibitors work by reducing the production of estrogen, a hormone that can promote the growth of certain types of cancer cells.
Used in Anti-diabetic Agent Development:
Furthermore, 1,9-Heptadecadiene-4,6-diyn-3-ol, (3S,9Z)is utilized in the development of anti-diabetic agents. These agents can help regulate blood sugar levels and improve insulin sensitivity, offering potential therapeutic benefits for individuals with diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 81203-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,2,0 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 81203-57:
(7*8)+(6*1)+(5*2)+(4*0)+(3*3)+(2*5)+(1*7)=98
98 % 10 = 8
So 81203-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H24O/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17(18)4-2/h4,10-11,17-18H,2-3,5-9,12H2,1H3/b11-10-/t17-/m0/s1
81203-57-8Relevant articles and documents
A short synthesis of (+) and (-)-falcarinol
McLaughlin, Noel P.,Butler, Eibhlín,Evans, Paul,Brunton, Nigel P.,Koidis, Anastasios,Rai, Dilip K.
experimental part, p. 9681 - 9687 (2011/02/25)
A short, practical synthesis of the bis-acetylenic natural product falcarinol 1 is reported. This method relies on the alternate functionalisation of bis-trimethylsilylbutadiyne 10. This may be achieved in one-pot, however, better yields were obtained more conventionally. Lipase mediated enzymatic kinetic resolution of the racemic adduct in an organic solvent afforded (+)-1 in 97% enantiomeric excess. The analogous process performed with racemic 3-acetoxy falcarinol 11 under aqueous conditions gave (-)-1. Oxidation of 1 with Dess-Martin periodinane gave falcarinone 2.
Absolute configuration of falcarinol, a potent antitumor agent commonly occurring in plants
Zheng, Guangrong,Lu, Wei,Aisa, Haji A.,Cai, Junchao
, p. 2181 - 2182 (2007/10/03)
The absolute configuration of falcarinol (1) was established by stereoselective total synthesis of the two enantiomers.