81323-58-2

Basic information

• Product Name: NW-09-15-1
• Synonyms: NW-09-15-1;(S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxybutanoate;N-Boc-L-hoMoserine Butyl Ester;N-t-Butyloxycarbonyl-L-hoMoserine-t-butyl ester;2-Methyl-2-propanyl N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-hoMoserinate;N-Boc-L-homoserine tert-butyl ester;-tert-Butyl 2-((tert-butoxycarbonyl);N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester
• CAS NO: 81323-58-2
• Molecular Formula: C₁₃H₂₅NO₅
• Molecular Weight: 275.342
• Mol File: 81323-58-2.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 393.353 °C at 760 mmHg
• Flash Point: 191.693 °C
• Appearance: /
• Density: 1.072 g/cm³
• Storage Temp.: 2-8°C
• PKA: 10.91±0.46(Predicted)
• CAS DataBase Reference: NW-09-15-1(CAS DataBase Reference)
• NIST Chemistry Reference: NW-09-15-1(81323-58-2)
• EPA Substance Registry System: NW-09-15-1(81323-58-2)

Safety Data

• Hazardous Substances Data: 81323-58-2(Hazardous Substances Data)

Usage

General Description

I'm sorry for the confusion, but it seems "NW-09-15-1" is not identified as a distinct chemical substance in available databases. This could be an internal labeling system or a product label within a specific company or research context, but without additional information, it's not possible to provide a summary for the chemical's properties or uses. To provide a complete summary, we need to know the accurate chemical name, formula or identifiers like the CAS Registry Number, PubChem CID or ChemSpider ID.

Upstream product

• 80963-08-2 N-tert-butoxycarbonyl-L-aspartic acid β-benzyl α-tert-butyl diester 
• 672-15-1 L-homoserine 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 41088-86-2 L-2-(tert-butyloxycarbonylamino)-4-hydroxybutyric acid 
• 507-19-7 t-butyl bromide 
• 34582-31-5 1-tert-butyl 4-methyl (S)-2-{[(tert-butoxy)carbonyl]amino}butanedioate 
• 59768-74-0 (S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester 
• 215182-75-5 (2S)-tert-butyl 2-[N-(9-(9-phenylfluorenyl))amino]-4-hydroxybutanoate 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 870-63-3 prenyl bromide 
• 34582-32-6 N-tert-butoxycarbonyl aspartic acid tert-butyl ester 

Downstream Products

• 1262523-46-5 (2S)-tert-butyl-2-(tert-butoxycarbonylamino)-4-(2-chloroacetoxy)-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 1262523-48-7 (2S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxy-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 1262523-50-1 (2S)-tert-butyl-2-(tert-butoxycarbonylamino)-5-oxo-4-(tosyloxy)-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 129740-14-3 tert-butyl (2S)-azetidine-2-carboxylate 

Relevant articles and documents

An efficient and scalable synthesis of Isodesmosine

Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.

Chemical synthesis of disulfide surrogate peptides by using beta-carbon dimethyl modified diaminodiacids

The replacement of disulfide bridges with metabolically stable isosteres is a promising strategy to improve the stability of disulfide-rich polypeptides towards reducing agents and isomerases. A diaminodiacid-based strategy is one of the most effective methods to construct disulfide bond mimics, but modified diaminodiacids have not been developed till now. Inspired by the fact that alkylation of disulfide bonds can regulate the activity of polypeptides, herein, we report the first example of thioether bridged diaminodiacids incorporating Cys Cβdimethyl modification, obtained by penicillamine (Pen)-based thiol alkylation. The utility of these new diaminodiacids was demonstrated by the synthesis of disulfide surrogates of oxytocin containing a short-span disulfide bond and of KIIIA with large-span disulfide bonds. This new type of synthetic bridge further extends the diaminodiacid toolbox to facilitate the study of the structure-activity relationship of disulfide-rich peptides.

Stereoselective Synthesis of Protected l - Allo -Enduracididine and l -Enduracididine via Asymmetric Nitroaldol Reaction

The diastereoselecetive and scalable synthesis of cyclic guanidine-containing nonproteinoginic amino acids, enduracididines, has been achieved. Both diastereomers, l - allo -enduracididine and l -enduracididine, were prepared via catalyst-controlled asymmetric nitroaldol reaction with the aldehyde precursor derived from l -aspartic acid. The cyclic guanidine of di-Cbz-protected l - allo -enduracididine was fully protected with an allyl group to suppress nucleophilic side reactions. Introduced allyl group was efficiently removed via π-allylpalladium chemistry without attaching the Cbz group on the cyclic guanidine moiety.