81447-33-8

Basic information

• Product Name: toluene-4-sulfonic acid 1-methyl-2-oxobutyl ester
• Synonyms: toluene-4-sulfonic acid 1-methyl-2-oxobutyl ester
• CAS NO: 81447-33-8
• Molecular Weight: 256.323
• Mol File: 81447-33-8.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid 1-methyl-2-oxobutyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid 1-methyl-2-oxobutyl ester(81447-33-8)
• EPA Substance Registry System: toluene-4-sulfonic acid 1-methyl-2-oxobutyl ester(81447-33-8)

Safety Data

• Hazardous Substances Data: 81447-33-8(Hazardous Substances Data)

Upstream product

• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 96-22-0 pentan-3-one 
• 104-15-4 toluene-4-sulfonic acid 
• 584-02-1 2-pentanol 
• 25370-97-2 O-(p-toluenesulfonyl)-N-methylhydroxylamine 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 16106-44-8 potassium tosylate 
• 25370-96-1 O-(p-toluenesulfonyl)-N-tert-butoxycarbonyl-N-methylhydroxylamine 

Relevant articles and documents

Evolution of N-Heterocycle-Substituted Iodoarenes (NHIAs) to Efficient Organocatalysts in Iodine(I/III)-Mediated Oxidative Transformations

The reactivity of ortho-functionalized N-heterocycle-substituted iodoarenes (NHIAs) as organocatalysts in iodine(I/III)-mediated oxidations was systematically investigated in the α-tosyloxylation of ketones as the model reaction. During a systematic catalyst evolution, it was found that NH-triazoles and benzoxazoles have the most significant positive influence on the reactivity of the central iodine atom. A further catalyst improvement which focused on the substitution pattern of the arene revealed a remarkable ortho-effect. By introduction of an o-OMe group we were able to generate a novel NHIA with a so far unseen catalytic efficiency. This new catalyst is not only easy to synthesize but also enabled the α-tosyloxylation of carbonyl compounds at the lowest reported catalyst loading of only 1 mol%. Finally, the performance of this iodine(I) catalyst was successfully demonstrated in intramolecular oxidative couplings of biphenyls and oxidative rearrangements. (Figure presented.).

Oxidative breakdown of iodoalkanes to catalytically active iodine species: A case study in the α-tosyloxylation of ketones

Catalysis of the oxidative processes by iodoarenes has become a promising direction in synthesis. The mechanism, involving the well-known isolable hypervalent iodine species, is generally limited to aromatic iodides, since the corresponding aliphatic spec

An iodobenzene-catalysed domino route toward quinoxaline derivatives from simple ketones and o-phenylenediamines in one pot

An iodobenzene-catalysed domino route to quinoxalines from ketones and o-phenylenediamines in one pot has been developed. This transformation consisted of the generation of Koser's generation, α-tosyloxylation of ketones, nucleophilic substitution and intramolecular dehydration with o-phenylenediamines, and dehydrogenation. Website